4-Chloro-8-fluoroquinoline TCI C3062

Name: TCI C3062 63010-72-0 4-Chloro-8-fluoroquinoline
Brand: TCI
SKU: TCI2510C306218001
Price: 2186100.0 IDR
Availability: InStock

Rp 2.186.100,00

Sale Sold out

Shipping calculated at checkout.

Berat 1g 5g

Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.

Description

TCI C3062 4-Chloro-8-fluoroquinoline is a heterocyclic compound of the quinoline class, carrying a chlorine substituent at position 4 and a fluorine atom at position 8 of its bicyclic nitrogen-containing framework. In organic synthesis laboratories, this compound serves as a starting material — a building block ready to be elaborated into more complex molecules. The quinoline scaffold itself is one of the most frequently encountered heterocyclic cores in medicinal chemistry research, dyes, and coordination ligands, so the availability of halogenated derivatives such as this one greatly simplifies the systematic construction of derivative compound libraries.

The characteristic that makes this material a preferred choice lies in the reactivity pattern of its functional groups. The chlorine at position 4 of the quinoline is activated toward nucleophilic aromatic substitution by the ring nitrogen atom, so it is readily displaced by amines, alkoxides, or thiols under relatively controlled conditions. Meanwhile, the fluorine atom at position 8 is generally retained in the final product, where it modulates the electronic properties, lipophilicity, and metabolic stability of the target molecule. The combination of one reactive site and one modulating substituent gives chemists predictable, selective control over the direction of the synthesis.

In Indonesian laboratories, this building block is typically used in university research groups, medicinal chemistry programmes, and industrial research units that develop quinoline derivatives. It is commonly handled on a small scale in fume hoods, weighed on analytical balances, and reacted in standard round-bottom glassware or sealed vials under inert conditions. Researchers preparing derivative series for screening rely on such halogenated intermediates because they shorten the route from a commercial starting material to a novel target structure.

Laboratory Applications

Nucleophilic aromatic substitution studies — the position-4 chlorine is activated by the ring nitrogen, making this an ideal substrate for teaching and probing SNAr reactivity with amines, alkoxides, and thiols.
Medicinal chemistry library synthesis — chemists can install diverse nucleophiles at the 4-position to generate systematic series of quinoline derivatives from a single, consistent starting scaffold.
Fluorinated lead compound development — the retained 8-fluoro substituent allows researchers to tune electronic character, lipophilicity, and metabolic stability of candidate molecules without an extra fluorination step.
Coordination chemistry and ligand preparation — the quinoline nitrogen makes derivatives of this compound useful as chelating ligands for metal complexes explored in catalysis and materials research.
Dye and functional material intermediates — the quinoline core is a recognised chromophore framework, so this halogenated derivative serves as an entry point into functionalised dye and specialty material syntheses.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS Number: 63010-72-0
Product Code: C3062
Chemical Name: 4-Chloro-8-fluoroquinoline
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Packaging: available in standard laboratory research pack sizes; please confirm the currently listed pack size when ordering
Storage: keep in the tightly closed original container in a cool, dry, well-ventilated place

Handling and Storage

Store this compound in its tightly closed original container in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, ignition sources, and incompatible materials such as strong oxidising agents. Amber glass or the supplier's original packaging is suitable, and the container should be reclosed promptly after each use to limit exposure to moisture and air. Handle the material inside a fume hood while wearing safety goggles, chemical-resistant gloves, and a laboratory coat, and avoid inhaling dust or allowing contact with skin and eyes. Weigh only the quantity required for the experiment, keep the container clearly labelled, and consult the manufacturer's Safety Data Sheet before first use. Dispose of residues and contaminated materials as chemical waste in accordance with the applicable institutional and local regulations.