Cefaclor Monohydrate TCI C3478

Chemical Identity

CAS No.: 70356-03-5
PubChem: CID 51038·SID 468591117
Formula: C15H14ClN3O4S.H2O
Molecular weight: 385.82 g/mol
Purity: >98.0%(HPLC)(T)
Storage: <0°C

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate
SMILES: C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl.O
InChIKey: WKJGTOYAEQDNIA-IOOZKYRYSA-N
MDL: MDL00071999

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Cefaclor Monohydrate from TCI (product code C3478) is a second-generation cephalosporin antibiotic that belongs to the beta-lactam family. The monohydrate is the form commonly used in oral pharmaceutical preparations. In the laboratory, it serves as a reference compound for microbiology, pharmacology, and pharmaceutical analysis. Cefaclor inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This disrupts peptidoglycan formation and causes the bacterial cell to lyse. Because of this mechanism, cefaclor is an important model compound in beta-lactam antibiotic research.

Researchers choose cefaclor because its activity against Gram-positive bacteria and some Gram-negative bacteria is well documented. This lets researchers compare their results directly with published literature. Its beta-lactam ring is susceptible to hydrolysis and to beta-lactamase enzymes. That sensitivity is useful for studies of stability, degradation, and resistance mechanisms. TCI supplies it as a chemical with a clearly defined identity. Laboratories can use it to prepare standard solutions, check chromatographic system suitability, and validate assay methods for content determination.

In Indonesia, antibiotic resistance is a growing concern for clinical, academic, and industrial laboratories. Cefaclor Monohydrate is relevant to university microbiology departments that study bacterial susceptibility and to pharmaceutical quality control laboratories that analyse cephalosporin products. Research institutions that investigate beta-lactamase activity also use it. AMI Scientific supplies this TCI reagent to laboratories across Indonesia that need a documented reference compound for routine analytical work and for research on beta-lactam antibiotics and their behaviour.

TCI brochures (PDF)

Immunology Research Reagents 2026-06-03 · p. 10
Antimicrobials and Antitumor Agents for Research and Experimental Use 2025-04-24 · p. 3
Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 3

Related TCI products

Antimicrobial susceptibility testing: cefaclor's activity against Gram-positive and some Gram-negative bacteria is well documented, so new results can be checked against existing published data.
Beta-lactam resistance studies: its beta-lactam ring is susceptible to beta-lactamase enzymes, which makes it a practical substrate for studying how resistant bacteria inactivate cephalosporin antibiotics.
Stability and degradation studies: the beta-lactam ring hydrolyses readily, so researchers can use cefaclor to observe degradation pathways and evaluate how storage or formulation conditions affect stability.
Chromatographic system suitability: as a chemical with a clearly defined identity, it can be used to confirm that HPLC or other chromatographic systems perform correctly before sample analysis.
Analytical method validation: laboratories can prepare standard solutions from this material to validate assay methods for cefaclor content in pharmaceutical products and research samples.

Brand	TCI (product code C3478)
CAS number	70356-03-5
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Antibiotics
Pack sizes	please refer to the available options on the product page
Physical form	—
Storage	follow the conditions stated on the TCI label and Safety Data Sheet

Compound: Cefaclor Monohydrate, a second-generation cephalosporin (beta-lactam)

Keep Cefaclor Monohydrate in its original, tightly closed container. Store it in a cool, dry place away from moisture, heat, and direct light, and follow the storage conditions on the TCI label and Safety Data Sheet. The beta-lactam ring is prone to hydrolysis, so limit exposure to humidity and prepare solutions fresh when possible. Handle the material with gloves, a laboratory coat, and eye protection, and avoid inhaling dust. Beta-lactam antibiotics can cause allergic sensitisation in some people, so take care to avoid skin contact and inhalation. Dispose of waste according to local regulations for pharmaceutical and chemical waste.

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