• 6-Chloro-2,4-dimethoxypyrimidine (CAS 6320-15-6) - TCI D1385 - AMI Scientific
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TCI

CAS 6320-15-6

6-Chloro-2,4-dimethoxypyrimidine TCI D1385

6-Chloro-2,4-dimethoxypyrimidine TCI D1385
Rp 916.650,00
Rp 916.650,00
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TCI D1385 6-Chloro-2,4-dimethoxypyrimidine is a nitrogen-containing heterocyclic compound built on a pyrimidine core that carries two methoxy groups together with a single chlorine atom. As a heterocyclic building block, this material occupies an important position in the synthesis of bioactive compounds, because the pyrimidine framework is a core motif found in many pharmaceutical and agrochemical active ingredients. In the laboratory, the compound generally serves as a ready-to-use starting material that can be functionalized further to construct pyrimidine derivatives with substituent patterns deliberately designed by the researcher.

The property that makes this compound a preferred choice is the reactivity of the chlorine atom on an electron-deficient ring. The pyrimidine core is electron-withdrawing, so the chlorinated position becomes highly susceptible to nucleophilic aromatic substitution by amines, alkoxides, or thiols under relatively controlled conditions. At the same time, the two methoxy groups act both as substituents and as groups that can be converted into hydroxyl functions or other leaving groups at a later stage. This clearly defined substitution pattern gives chemists a clean route toward substituted pyrimidine derivatives with an efficient number of synthetic steps.

For Indonesian laboratories, this building block fits routine synthetic work in university research groups, pharmaceutical and agrochemical development laboratories, and industrial R&D units that prepare pyrimidine-based target molecules. It is typically used at bench scale for method development, derivative libraries, and step-by-step route exploration, where a well-defined starting material with predictable reactivity shortens the path from planned structure to isolated product and keeps synthetic protocols reproducible between operators and between batches of work.

  • Nucleophilic aromatic substitution studies — the electron-deficient pyrimidine ring activates the chlorinated position toward amines, alkoxides, and thiols under relatively controlled reaction conditions.
  • Synthesis of pyrimidine derivatives — the defined substitution pattern lets chemists install chosen substituents in a directed way while keeping the overall step count efficient.
  • Pharmaceutical intermediate preparation — the pyrimidine framework is a core motif in many active pharmaceutical ingredients, making this a practical starting material for medicinal chemistry routes.
  • Agrochemical research synthesis — pyrimidine-based scaffolds also appear widely in agrochemical active ingredients, so this building block supports development of new candidate structures.
  • Methoxy group transformation chemistry — the two methoxy substituents can be converted into hydroxyl functions or other leaving groups at a later stage of a multi-step sequence.

Brand TCI
CAS number 6320-15-6
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes available in standard laboratory packaging; please confirm the pack size options when ordering
Physical form —
Storage keep in a tightly closed original container in a cool, dry place, following the manufacturer's stated storage conditions on the label and safety data sheet
  • Product code: D1385
  • Chemical name: 6-Chloro-2,4-dimethoxypyrimidine

Store the material in its original tightly closed container in a cool, dry, well-ventilated area, away from moisture, direct sunlight, and incompatible reagents, and always follow the storage conditions stated by the manufacturer on the product label and safety data sheet. Use clean, dry glassware and spatulas when weighing to avoid contamination and moisture uptake, and reseal the container promptly after each use. Handle the compound in a fume hood while wearing safety goggles, a laboratory coat, and suitable chemical-resistant gloves. Avoid inhalation of dust and direct contact with skin or eyes. Review the safety data sheet before first use, label all working solutions clearly, and dispose of residues and contaminated materials through the laboratory's chemical waste procedures.

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