Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.
Couldn't load pickup availability
Description
TCI D4723 4,6-Dichloro-5-methoxypyrimidine is a heterocyclic compound built on a pyrimidine core that carries two chlorine atoms at the 4- and 6-positions together with a methoxy group at the 5-position. As a heterocyclic building block, this material is widely used to construct substituted pyrimidine frameworks, a structural motif found at the centre of many research-relevant molecules. Its primary role in the laboratory is that of an electrophilic substrate: both chlorinated positions can be displaced by a broad range of nucleophiles through nucleophilic aromatic substitution, allowing researchers to install amine, alkoxy, or thio groups step by step on the same framework.
The characteristic that makes this compound sought after is its ability to undergo substitution sequentially. The first reaction can generally be carried out under relatively mild conditions, whereas displacement of the second chlorine requires more forcing conditions such as heating or a stronger base. This difference in reactivity between the two positions creates an opportunity to introduce two different nucleophiles in a controlled manner — a highly efficient strategy in the preparation of compound libraries. The methoxy group at the 5-position influences the electron density of the ring while also serving as a defining structural feature of the molecule.
In Indonesian laboratories, this building block is typically used in synthetic organic chemistry and medicinal chemistry research settings, where substituted pyrimidine scaffolds are assembled as intermediates for further study. It suits university research groups, government research institutes, and industrial R&D laboratories that carry out multi-step synthesis on a bench scale and require a reliable heterocyclic starting material for exploratory work and small-scale library preparation.
Laboratory Applications
Synthesis of substituted pyrimidines — the two reactive chlorine positions allow researchers to build a wide variety of pyrimidine derivatives from a single, well-defined starting framework.
Nucleophilic aromatic substitution studies — the activated chlorinated ring serves as a clear model substrate for teaching and investigating displacement reactions with amine, alkoxy, and thio nucleophiles.
Sequential difunctionalisation — the differing reactivity of the 4- and 6-positions lets chemists introduce two distinct nucleophiles in a controlled order without protecting group strategies.
Compound library preparation — controlled stepwise substitution on one common core makes this building block efficient for generating sets of structurally related analogues for screening.
Medicinal chemistry intermediate synthesis — the pyrimidine motif is a core structure in many research-value molecules, making this material useful for preparing intermediates in discovery programmes.
Specifications
Brand: TCI
CAS number: 5018-38-2
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Product code: TCI D4723
Pack sizes: available in standard TCI research pack sizes; please confirm the size required when ordering
Storage: store in a cool, dry, well-ventilated area in the original tightly closed container
Handling and Storage
Store this material in its original tightly closed container in a cool, dry, well-ventilated place, away from moisture, direct sunlight, and sources of heat or ignition. Keep it separated from strong bases and strong nucleophiles, since the chlorinated positions are reactive towards nucleophilic attack. Handle in a fume hood using appropriate personal protective equipment, including safety glasses, chemical-resistant gloves, and a laboratory coat, and avoid the generation and inhalation of dust. Transfer with clean, dry spatulas and reseal the container promptly after use. Always consult the manufacturer's Safety Data Sheet before handling, and follow your institution's procedures for chemical waste disposal.
![4-([1,1'-Biphenyl]-4-yl)-6-chloro-2-phenylpyrimidine (CAS 1689538-58-6) - TCI B5802 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B5802.jpg?v=1768815900&width=533)
