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Description
TCI D2590 3,3-Diphenylpropionitrile is a non-heterocyclic building block consisting of a propionitrile chain bearing two phenyl rings attached to the carbon atom at the third position. The nitrile group at the end of the chain is one of the most versatile functional groups in organic chemistry, because it can be converted into primary amines, carboxylic acids, amides, aldehydes, ketones, and certain heterocyclic rings. The compound therefore serves as a starting material that carries a diphenylmethane framework together with a single, clearly defined reactive point, allowing researchers to design directed downstream transformations in the synthesis laboratory.
The characteristics that make this compound a preferred choice are the stability of its rigid, lipophilic diphenyl framework combined with a nitrile group that is reactive yet not easily degraded during storage. The two aromatic rings provide steric volume and hydrophobic character, which is useful when researchers wish to tune the solubility of a target molecule or its interaction with biological receptors. The hydrogen atoms on the carbon alpha to the nitrile are sufficiently acidic to be deprotonated, forming a carbanion that is useful in alkylation reactions. As a stable solid, the material is straightforward to weigh and handle on the bench.
In Indonesian laboratories, this building block is typically used in university and institutional organic synthesis groups, in medicinal chemistry research directed at candidate molecules, and in method development work where a defined aromatic scaffold with a single reactive handle is required. It suits multi-step synthesis routes carried out on a research scale, where a starting material must remain stable between reaction steps and be reliably reproducible from batch to batch under local laboratory conditions.
Laboratory Applications
- Organic synthesis starting material: the single nitrile handle on a stable diphenyl framework lets researchers plan directed multi-step routes without competing reactive sites.
- Nitrile-to-amine conversion studies: reduction of the terminal nitrile yields primary amines, giving a convenient entry point into amine-based intermediates for further functionalisation work.
- Carboxylic acid and amide preparation: hydrolysis of the nitrile group provides carboxylic acids or amides while the diphenylmethane scaffold remains intact throughout the transformation.
- Alkylation chemistry via carbanion formation: the acidic alpha hydrogens can be deprotonated to generate a carbanion, enabling controlled carbon–carbon bond formation at that position.
- Medicinal chemistry scaffold development: the lipophilic, sterically bulky two-ring system helps researchers tune solubility and receptor interaction when designing candidate molecules.
Specifications
- Brand: TCI
- CAS number: 2286-54-6
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Product code: D2590
- Physical form: solid at ordinary laboratory conditions
- Pack sizes: available in standard TCI research-scale packaging; please confirm the required size when ordering
- Storage: keep in a closed container in a cool, dry place away from light
Handling and Storage
Store the material in its original tightly closed container, in a cool, dry, well-ventilated place away from direct sunlight, heat sources, and incompatible reagents. Amber glass or the supplier's original packaging is suitable, and containers should be resealed immediately after each use to limit moisture uptake and contamination. Handle the solid in a fume hood, using gloves, safety glasses, and a laboratory coat, and avoid generating dust during weighing and transfer. Use clean, dry spatulas to preserve batch integrity. Follow the manufacturer's safety data sheet and your institution's chemical waste procedures for disposal of residues and contaminated materials.
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