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Description
TCI D2634 2,5-Diamino-4,6-dihydroxypyrimidine Hydrochloride (CAS 56830-58-1) is the hydrochloride salt of a pyrimidine bearing two amino groups and two hydroxy groups on a six-membered nitrogen-containing heterocyclic ring. The pyrimidine skeleton is one of the most important motifs in biological chemistry because it forms the core of the nitrogenous bases that make up nucleic acids. In the laboratory, this compound serves as a heterocyclic starting material for constructing fused ring systems, particularly pteridine frameworks and folate derivatives, as well as an intermediate in the synthesis of active compounds and dye materials.
The property that makes this building block so widely chosen is the density of functional groups packed onto a relatively small ring. The two amino groups provide nucleophilic centres that are ready to condense with carbonyl compounds, while the hydroxy groups at the 4- and 6-positions can undergo keto–enol tautomerism and can be activated into leaving groups, for example through chlorination, opening the way for further substitution. The hydrochloride salt form generally improves solubility in water and offers better storage stability than the corresponding free base, given that electron-rich aminopyrimidines tend to oxidise readily.
In Indonesian laboratories, this reagent is typically used in university and institutional research settings working on heterocyclic synthesis, medicinal chemistry, and pharmaceutical intermediate development. It suits organic synthesis groups building pteridine and folate-related scaffolds, as well as analytical and quality control units that require a well-defined reference building block. Its salt form is a practical advantage under Indonesia's warm and humid conditions, where free-base aminopyrimidines are more vulnerable to degradation during storage.
Laboratory Applications
Pteridine ring construction: the adjacent diamino arrangement condenses readily with dicarbonyl partners, allowing the bicyclic pteridine core to be assembled in a direct and reliable annulation step.
Folate derivative synthesis: the compound supplies the pyrimidine portion of the folate skeleton, making it a logical entry point for preparing pterin and folate-related target molecules in research programmes.
Pharmaceutical intermediate preparation: as a densely functionalised heterocycle, it shortens synthetic routes toward biologically active candidates that require an aminopyrimidine core carrying further substitution.
Dye and colourant chemistry: the electron-rich aminopyrimidine ring participates in coupling and condensation reactions that generate chromophoric systems used in the preparation of dye materials.
Halogenation and substitution studies: the 4- and 6-hydroxy groups can be converted into leaving groups by chlorination, giving a versatile platform for exploring nucleophilic aromatic substitution chemistry.
Specifications
Brand: TCI
CAS Number: 56830-58-1
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Chemical form: hydrochloride salt of 2,5-diamino-4,6-dihydroxypyrimidine
Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required quantity when ordering
Storage note: keep in a tightly closed container, protected from moisture and air
Handling and Storage
Store the material in its original tightly closed container in a cool, dry, and well-ventilated area, away from direct sunlight and sources of heat or ignition. Amber glass bottles or the manufacturer's original packaging are suitable, and a desiccator or sealed secondary container helps limit moisture uptake in humid conditions. Because electron-rich aminopyrimidines are prone to oxidation, minimise unnecessary exposure to air and close the container promptly after each use. Handle the solid in a fume hood or a well-ventilated workspace, wear a laboratory coat, chemical-resistant gloves, and safety goggles, and avoid generating dust during weighing and transfer. Consult the manufacturer's safety data sheet before use and dispose of residues through approved chemical waste channels.
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