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Description
TCI D2707 2,4-Dimethoxy-4'-hydroxybenzophenone is a synthetic chemical from TCI classified as a non-heterocyclic building block. The compound is built on a benzophenone skeleton, that is, two aromatic rings joined by a carbonyl group, carrying two methoxy groups on one ring and one free hydroxyl group on the other. In the laboratory, substituted benzophenone frameworks of this kind serve as starting materials for the synthesis of polyphenolic compounds, as precursors to flavonoid and xanthone analogues, and as model molecules in studies of ultraviolet light absorption.
The property that makes this material a frequent choice is the unsymmetrical substitution pattern between its two aromatic rings. The methoxy groups act as electron-donating groups and at the same time as protected latent hydroxyl groups, since they can be demethylated to reveal additional phenolic functionality at a late stage of a synthesis. The free hydroxyl group on the opposite ring provides a direct reaction site for etherification, esterification, and coupling. The carbonyl group between the two rings maintains conjugation across the whole molecule, so the compound shows strong ultraviolet absorption — a characteristic that is useful both for reaction monitoring and for studies of ultraviolet-absorbing materials.
In Indonesian laboratories, a building block of this type is typically used in organic synthesis groups at universities and research institutes, in natural product chemistry work directed at flavonoid and xanthone analogues, and in materials or formulation studies where ultraviolet absorption behaviour is examined. It is normally handled on a small preparative scale at the bench, with reaction progress followed spectroscopically, and it is stored alongside other fine synthetic reagents in the laboratory chemical store.
Laboratory Applications
Synthesis of polyphenolic compounds — the combination of a free phenolic hydroxyl group and two demethylatable methoxy groups allows several hydroxyl positions to be revealed in a controlled sequence.
Preparation of flavonoid analogues — the benzophenone core with its unsymmetrical ring substitution provides the two-aromatic-ring arrangement required as a starting framework for building flavonoid-type structures.
Preparation of xanthone analogues — the carbonyl bridge between the two aromatic rings gives the skeletal arrangement needed for cyclisation approaches toward xanthone-type target molecules.
Ultraviolet absorption studies — full conjugation through the carbonyl group produces strong ultraviolet absorption, making the compound a useful model molecule for examining ultraviolet-absorbing behaviour.
Etherification, esterification, and coupling chemistry — the free hydroxyl group on the ring opposite the methoxy substituents acts as a direct and selective handle for these transformations.
Specifications
Brand: TCI
Product code: D2707
CAS number: 41351-30-8
Chemical name: 2,4-Dimethoxy-4'-hydroxybenzophenone
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required pack size when ordering
Storage: store in the closed original container, in a cool, dry, well-ventilated place away from light
Handling and Storage
Keep the material in its original tightly closed container and store it in a cool, dry, well-ventilated area, protected from direct sunlight and away from heat sources and incompatible reagents. Because the compound absorbs ultraviolet light strongly, storage in amber or otherwise light-protected glass containers is advisable for long-term use. Handle it in a fume hood using standard laboratory personal protective equipment — safety glasses, a laboratory coat, and suitable chemical-resistant gloves — and avoid the generation of dust as well as contact with skin and eyes. Reseal the container promptly after weighing, label all working solutions clearly, and consult the manufacturer's safety data sheet before first use and before disposal of residues.
