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Description
TCI D3426 3,5-Difluoronitrobenzene is a synthesis chemical belonging to the fluorinated nitroarene class, carrying a nitro group on the benzene ring together with two fluorine atoms at the 3 and 5 positions. Its role in the laboratory is highly specific: it serves as a dependable substrate for nucleophilic aromatic substitution reactions and as a direct precursor toward fluorinated anilines. Because the symmetrical substitution pattern is already established, this material saves the nitration and fluorination steps that normally demand harsh conditions, hazardous reagents, and regioselectivity control that is difficult to achieve in small-scale laboratory work.
The property that makes this material a frequent choice is the strength of the nitro group, which acts as both an electron-withdrawing group and a reaction director. The nitro group renders the ring strongly electron-poor, so the fluorine atoms become responsive leaving groups toward attack by oxygen, nitrogen, and sulfur nucleophiles under relatively mild conditions. Once the substitution step is complete, the nitro group itself can be reduced to a primary amine through catalytic hydrogenation or metal-mediated reduction, opening routes toward the formation of amides, sulfonamides, diazonium salts, and a wide range of heterocyclic rings.
In Indonesian laboratories, this building block is typically used in university and institutional research groups, medicinal chemistry and agrochemical discovery programs, and process development work where fluorinated intermediates are required. It is commonly ordered for multi-step synthetic routes in which a pre-fluorinated, pre-nitrated aromatic core removes the need to run difficult nitration and fluorination steps in-house, and it is handled on the bench in fume hoods during small- to moderate-scale reaction work.
Laboratory Applications
- Nucleophilic aromatic substitution studies — the electron-poor ring activated by the nitro group allows fluorine displacement by oxygen, nitrogen, and sulfur nucleophiles under relatively mild laboratory conditions.
- Synthesis of fluorinated anilines — the nitro group is reduced to a primary amine by catalytic hydrogenation or metal reduction, giving direct access to fluorinated aniline intermediates.
- Heterocyclic ring construction — the amine generated after nitro reduction serves as a handle for building diverse heterocyclic ring systems in multi-step synthetic sequences.
- Amide and sulfonamide preparation — the primary amine obtained from reduction is readily acylated or sulfonylated, making this compound a practical entry point for amide and sulfonamide libraries.
- Diazonium chemistry — after reduction to the aniline, diazotization opens further functional group transformations on the fluorinated aromatic core without additional ring-building steps.
Specifications
- Brand: TCI
- CAS number: 2265-94-3
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Physical form: liquid
- Pack sizes: available in standard laboratory research pack sizes as supplied by the manufacturer
- Storage: store in a tightly closed container in a cool, dry, well-ventilated area away from heat and incompatible materials
Handling and Storage
Store this material in its original tightly closed container in a cool, dry, and well-ventilated place, away from heat sources, ignition sources, oxidizing agents, and strong bases. Use containers that are chemically compatible with the product and keep them clearly labelled with the compound name and CAS number. All handling, transfer, and weighing should be carried out inside a functioning fume hood, using appropriate personal protective equipment such as chemical-resistant gloves, safety goggles, and a laboratory coat. Avoid inhalation of vapours and direct skin or eye contact. Keep the container closed when not in use to limit vapour release, and dispose of residues and contaminated materials as chemical waste according to the laboratory waste management procedures in force. Always consult the manufacturer's Safety Data Sheet before use.
