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Description
TCI D3985 2,6-Difluoro-4-hydroxybenzoic Acid is a fluorinated building block that carries three functional groups on a single benzene ring: a carboxylic acid, a phenolic hydroxyl group, and two fluorine atoms flanking the carboxyl group. This arrangement of substituents makes it a highly useful starting material in organic synthesis, particularly for constructing molecules that require a combination of multiple reactive sites and the electronic influence of fluorine atoms. In the laboratory, the compound is commonly used as a core fragment in the design of active molecules as well as functional materials.
The properties that make it a frequent choice relate to the influence of the two fluorine atoms positioned ortho to the carboxyl group. Fluorine is strongly electron-withdrawing, which increases the acidity of both the carboxylate and the phenol, while at the same time introducing steric hindrance that affects molecular geometry. In medicinal chemistry, the incorporation of fluorine is commonly carried out to modulate metabolic properties, lipophilicity, and the interaction of molecules with biological targets. The phenolic hydroxyl group provides a site for etherification or esterification, while the carboxyl group is ready to be converted into amides, esters, or acid chlorides.
Because these three functional groups sit on one compact scaffold, the material fits naturally into the day-to-day work of Indonesian research laboratories, university chemistry departments, and industrial R&D units engaged in multi-step synthesis. It is typically drawn on for exploratory route development and small-scale preparation of intermediates, where a well-defined, ready-to-derivatize fluorinated aromatic core saves several preparatory steps and lets researchers concentrate on the later stages of a synthetic sequence.
Laboratory Applications
- Medicinal chemistry intermediate synthesis — the fluorinated aromatic core is used to build candidate molecules whose metabolic behavior, lipophilicity, and target interaction are modulated by the two fluorine substituents.
- Amide and ester derivative preparation — the carboxylic acid group is readily converted into amides, esters, or acid chlorides, giving a direct entry point into libraries of related derivatives.
- Etherification and esterification at the phenol — the phenolic hydroxyl group provides a second, chemically distinct handle for selective functionalization independent of the carboxyl group.
- Functional material development — the compound serves as a core fragment when designing functional materials that require an aromatic scaffold with defined electronic character and multiple attachment points.
- Multi-step organic synthesis route development — the combination of three functional groups on one ring gives synthetic chemists several reaction points to exploit in sequential transformations.
Specifications
- Brand: TCI
- CAS number: 214917-68-7
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Chemical name: 2,6-Difluoro-4-hydroxybenzoic Acid
- Pack sizes: available in standard TCI research-scale packaging; please confirm the size options when ordering
- Storage: store according to the conditions stated on the product label and the accompanying safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated area, away from direct sunlight, moisture, and sources of heat or ignition. Keep the material in its original supplier container or in a chemically compatible, clearly labeled vessel, and reseal it promptly after each use to limit moisture uptake. As with any organic acid, handle the solid in a fume hood and wear appropriate personal protective equipment, including safety goggles, gloves, and a laboratory coat. Avoid dust formation, contact with skin and eyes, and inhalation. Segregate it from strong bases and strong oxidizing agents, and always consult the safety data sheet supplied with the product before use and before disposal.
