TCI
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Description
TCI D4200 Fialuridine, CAS number 69123-98-4, is a halogenated nucleoside analogue supplied as a biochemical reagent within the antibiotics group for research purposes. The molecule is a pyrimidine derivative carrying a halogen substituent together with a fluorinated arabinofuranose sugar, a combination that makes it closely resemble a naturally occurring nucleoside while behaving differently when it encounters enzymes that process nucleic acids. In the laboratory, this compound serves as a test substance in antiviral research, nucleoside metabolism studies, and molecular probe development, and it is intended entirely for experimental work.
The property that makes this compound important to researchers is the structural similarity it shares with the natural substrates of certain viral kinase enzymes, which allows it to be phosphorylated selectively inside cells that express those enzymes. This characteristic has made fialuridine a classic model in the development of gene reporter systems and in selective targeting research. The presence of a halogen atom on the pyrimidine ring influences the electronic properties of the molecule and opens the possibility of isotopic labelling for imaging studies. The compound also carries a well-documented historical record in the scientific literature.
In Indonesian laboratories, this reagent is handled within research settings such as university biochemistry and molecular biology laboratories, virology research groups, and institutional research units working on nucleoside chemistry. It is prepared and used by trained personnel under controlled conditions, with dispensing carried out in the quantities required for each experimental run. Because it is designated strictly for experimental activity, it is documented and tracked in the same way as other research-grade biochemical reagents held in the laboratory inventory.
Laboratory Applications
- Antiviral research assays — the compound acts as a nucleoside analogue test substance in experimental systems that examine how modified nucleosides interact with viral replication machinery.
- Nucleoside metabolism studies — its close resemblance to natural nucleosides allows researchers to trace how enzymes recognise, accept, or reject substrate analogues within metabolic pathways.
- Molecular probe development — the halogenated pyrimidine ring provides a chemical handle that supports the design of probes for detecting and following biological targets.
- Gene reporter system development — selective phosphorylation in cells expressing particular viral kinase enzymes makes this compound a classic model for building reporter-based experimental readouts.
- Selective targeting research — because activation depends on the presence of a specific enzyme, it serves as a reference model for studies exploring enzyme-dependent selectivity in cells.
Specifications
- Brand: TCI
- CAS Number: 69123-98-4
- Category: Life Science > Biochemicals and Reagents > Antibiotics
- Chemical class: halogenated nucleoside analogue; pyrimidine derivative with a fluorinated arabinofuranose sugar
- Pack sizes: available in standard TCI research pack sizes; please confirm the required size when ordering
- Storage: store under the conditions stated on the manufacturer's label and product documentation
Handling and Storage
Store the container tightly closed in the conditions specified by the manufacturer's label, keeping it away from moisture, direct sunlight, and sources of heat. Original manufacturer packaging or chemically compatible amber glass or inert plastic vials are suitable for storage, and any aliquots prepared should be clearly labelled with the compound name, CAS number, and preparation date. Handle only in a well-ventilated area or a fume hood, wearing a laboratory coat, safety glasses, and suitable gloves. Avoid inhalation of dust and direct contact with skin and eyes. As a research-use-only biochemical reagent, it should be handled exclusively by trained personnel who have reviewed the manufacturer's safety data sheet before use, and residues should be collected and disposed of through the laboratory's chemical waste procedures.
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