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Description
TCI D4331 Detomidine Hydrochloride is the hydrochloride salt form of detomidine, an imidazole-framework compound known as an alpha-2 adrenergic receptor agonist. The product is supplied by TCI as a pharmaceutical research reagent intended for experimental laboratory use only, and is not for therapeutic application in humans or animals. Within a research setting, this compound serves as a comparative ligand in receptor pharmacology studies, as an analytical standard in the development of detection methods, and as a test substance in experimental pharmacokinetic and toxicology investigations.
The characteristics that make this material a preferred choice are its high selectivity toward the alpha-2 receptor subtype and the practical advantages of its salt form. As a hydrochloride, the compound is considerably more soluble in water and aqueous media than its free base, so preparing stock solutions for receptor binding assays, cell culture work, and chromatographic analysis is easier and more reproducible. The salt form is also generally more stable during storage and easier to weigh accurately in small quantities. The imidazole ring and methylated aromatic group give the molecule distinctive spectroscopic characteristics that support reliable identification and confirmation.
In Indonesian laboratories, this reagent is typically used in university pharmacology and pharmacy research groups, veterinary science faculties, and analytical laboratories that develop and validate detection methods. It is handled in small quantities on the analytical bench, where accurate weighing and reproducible stock solution preparation matter more than bulk volume. Users generally work within an experimental research framework, applying the material to receptor studies, method development, and instrumental analysis rather than to any clinical or therapeutic purpose.
Laboratory Applications
- Receptor pharmacology studies — serves as a comparative alpha-2 adrenergic ligand, allowing researchers to benchmark binding behaviour and characterise receptor subtype responses in controlled experimental systems.
- Analytical method development — functions as a reference standard when establishing and validating detection procedures, giving a defined compound against which instrument response and method performance can be calibrated.
- Receptor binding assays — the water-soluble hydrochloride form dissolves readily in aqueous buffers, so stock solutions for binding experiments can be prepared quickly and reproduced consistently between runs.
- Experimental pharmacokinetic and toxicology research — used as a test substance in laboratory studies, where its well-defined salt form supports accurate dosing calculations and consistent preparation across experimental groups.
- Chromatographic and spectroscopic analysis — the imidazole ring and methylated aromatic group provide distinctive spectroscopic features that assist identification, peak confirmation, and structural verification during instrumental work.
Specifications
- Brand: TCI
- CAS number: 90038-01-0
- Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
- Pack sizes: supplied in TCI standard research reagent pack sizes; please confirm the available packaging option when ordering
- Physical form: hydrochloride salt of detomidine, supplied as a solid research reagent
- Storage note: keep in the original tightly closed container under the storage conditions stated by the manufacturer on the product label
Handling and Storage
Store the container tightly closed in a cool, dry place, protected from moisture and direct light, and follow the storage conditions indicated by the manufacturer on the product label. Keep the material in its original supplier container, or transfer it to a clean, chemically compatible, well-sealed vial that is clearly labelled with the compound name and CAS number. Handle the reagent in a well-ventilated area or fume hood using appropriate personal protective equipment, including gloves, safety glasses, and a laboratory coat. Avoid generating dust when weighing, use dedicated clean spatulas to prevent cross-contamination, and keep the container closed when not in active use. Because this is a pharmaceutical research reagent for experimental use only, restrict access to trained laboratory personnel, record its use in laboratory documentation, and dispose of residues and contaminated materials as chemical waste according to institutional procedures.
