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Description
TCI D4814 is 2,4-Dichloro-6-morpholino-1,3,5-triazine, a symmetrical triazine derivative in which one ring position has been substituted with a morpholine ring while the two remaining positions still carry reactive chloride groups. The material belongs to the heterocyclic building block family, meaning it is a starting material chemists use to construct larger and more complex molecular frameworks. In organic synthesis laboratories, a compound of this type serves as the point of departure for stepwise reactions, because a chemist can replace the first chloride and then the second chloride under different conditions, allowing the architecture of the target molecule to be assembled in a controlled and deliberate manner.
The characteristic that makes this compound a frequent choice is the difference in reactivity between positions on the 1,3,5-triazine core. The morpholine group already installed on the ring acts as an electron donor and improves solubility in common organic solvents, while the two remaining chlorides stay open to attack by nucleophiles such as amines, alcohols, or thiols. This behaviour gives researchers a level of regioselective control that is rarely available from other starting materials. The triazine core is also recognised for its thermal and chemical stability, so the scaffold survives the reaction sequence intact.
In Indonesian laboratories, a building block of this kind is typically found in organic synthesis and medicinal chemistry research groups at universities, in research institutes, and in the development units of the pharmaceutical and specialty chemical industries. It is normally used at bench scale for the preparation of triazine derivative series, where researchers need a dependable intermediate that behaves predictably across a planned sequence of substitution steps and supports reproducible route development.
Laboratory Applications
- Stepwise nucleophilic substitution synthesis — the two remaining chlorides can be replaced sequentially under different conditions, letting chemists build asymmetrically substituted triazines with controlled regioselectivity.
- Medicinal chemistry scaffold preparation — the stable triazine core with a pre-installed morpholine group provides a convenient starting point for generating series of related derivatives for structure-activity studies.
- Amine coupling chemistry — the reactive chloride positions readily accept primary and secondary amine nucleophiles, making this material suitable for constructing amino-triazine frameworks in a planned order.
- Synthesis of alcohol and thiol derivatives — because alkoxides and thiols also displace the chlorides, the compound supports the preparation of ether- and thioether-linked triazine products.
- Route development and reference synthesis — the predictable reactivity difference between ring positions makes this building block useful for establishing and reproducing multi-step synthetic routes in the laboratory.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS Number: 6601-22-5
- Chemical Name: 2,4-Dichloro-6-morpholino-1,3,5-triazine
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Pack Sizes: available in standard TCI catalogue research pack sizes; please confirm the currently available packaging when ordering
- Storage: store in a tightly closed container in a cool, dry place, away from moisture
Handling and Storage
Store the material in its original tightly closed container in a cool, dry, well ventilated area, kept away from moisture and from incompatible reagents such as strong bases and nucleophiles. Because the chloride positions on the triazine ring are reactive, containers should be resealed promptly after each use and handled with dry glassware or dry spatulas to limit exposure to atmospheric humidity. All handling should be carried out in a functioning fume hood, wearing a laboratory coat, safety glasses, and chemically resistant gloves. Weigh and transfer the solid carefully to avoid generating dust, and consult the manufacturer's safety data sheet before use for detailed hazard, first aid, and disposal information. Dispose of residues and contaminated materials in accordance with the applicable chemical waste procedures at your institution.
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