7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one TCI D4824

Name: TCI D4824 73942-87-7 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one
Brand: TCI
SKU: TCI2510D482425542
Price: 2067450.0 IDR
Availability: InStock

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Berat 1g 5g

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Description

TCI D4824 is 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one, a heterocyclic compound built around a benzazepinone framework: a seven-membered nitrogen-containing ring fused to a benzene ring that carries two methoxy substituents. As a heterocyclic building block, this compound is widely used as an intermediate in multi-step organic synthesis, particularly in routes directed toward molecules bearing a benzazepine skeleton. In the laboratory, having a ready-to-use intermediate of this kind removes several early synthetic steps, allowing researchers to move directly to the structural modification stage that sits at the core of their research question.

The properties that make this compound a preferred choice are the combination of a seven-membered lactam ring and the two methoxy groups on the aromatic ring. The lactam group supplies an amide nitrogen that can be alkylated or acylated, together with a carbonyl that can be reduced to change the character of the ring. The methoxy groups are electron-donating, activating the aromatic ring toward electrophilic substitution at specific positions, and they can also be demethylated to hydroxyl groups when required. The seven-membered ring provides a more flexible conformation than smaller fused ring systems, which is often the reason this scaffold is selected in the first place.

In Indonesian laboratories, this material is typically handled in organic synthesis and medicinal chemistry research groups at universities, government research institutes, and industrial R&D units. It is normally ordered in small research quantities for method development and route exploration rather than for bulk processing, and is used within a workflow where the intermediate is carried forward through subsequent reaction, purification, and characterisation steps under standard laboratory conditions.

Laboratory Applications

Multi-step organic synthesis: serves as a ready-made intermediate that shortens the route by removing the need to construct the benzazepinone core from simpler starting materials.
Benzazepine scaffold construction: provides the fused seven-membered nitrogen ring already assembled, so work can begin directly at the substitution and functionalisation stage of the target molecule.
Medicinal chemistry exploration: the lactam nitrogen and carbonyl offer two independent handles for building analogue series around a single conserved heterocyclic core structure.
N-alkylation and N-acylation studies: the amide nitrogen of the lactam ring can be derivatised selectively, making this compound a convenient substrate for reaction condition screening and optimisation.
Aromatic substitution and demethylation work: the electron-donating methoxy groups activate defined ring positions and can be converted to hydroxyl groups when a phenolic intermediate is needed.

Specifications

Brand: TCI
CAS Number: 73942-87-7
Chemical name: 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes: available in standard research-scale packaging as supplied by the manufacturer
Storage: store according to the manufacturer's instructions on the product label and safety data sheet

Handling and Storage

Store the container in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible chemicals, following the storage conditions stated on the product label and safety data sheet. Keep the material tightly closed in its original supplier container, or in a clean, chemically compatible and clearly labelled vessel if transferred. Handle in a fume hood using appropriate personal protective equipment, including safety glasses, a laboratory coat, and suitable chemical-resistant gloves. Avoid inhalation of dust and contact with skin and eyes. Reseal the container promptly after weighing to limit moisture uptake, and dispose of any residues and contaminated materials in accordance with applicable laboratory chemical waste procedures.