4-Ethylbenzenesulfonamide TCI E0773

Name: TCI E0773 138-38-5 4-Ethylbenzenesulfonamide
Brand: TCI
SKU: TCI2510E077328546
Price: 856800.0 IDR
Availability: InStock

Rp 856.800,00

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Berat 5g 25g

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Description

TCI E0773 4-Ethylbenzenesulfonamide is a non-heterocyclic building block consisting of a primary aromatic sulfonamide bearing an ethyl group at the para position of the benzene ring. The compound supplies a pre-formed arylsulfonamide framework, allowing researchers to modify the nitrogen centre directly or to employ the molecule as a binding fragment in molecular design. In the laboratory, the sulfonamide motif is widely recognised for its capacity to form strong hydrogen bonds and to interact with metal centres in target proteins, which is why this material appears frequently in medicinal chemistry research, enzyme inhibitor studies, and the development of other functional compounds and materials.

The properties that make this reagent a preferred choice are its stability and its ease of handling. Unlike moisture-sensitive sulfonyl chlorides, this sulfonamide is a solid that remains stable under ordinary storage conditions, is straightforward to weigh out, and does not demand an inert atmosphere. The sulfonamide NH₂ group is sufficiently acidic to be deprotonated and then alkylated, arylated through catalytic coupling, or acylated to give N-substituted derivatives. The ethyl substituent on the ring contributes lipophilicity, which is useful when researchers are tuning the physical character of a target structure.

In Indonesian laboratories, this building block is typically drawn upon in university and institutional research groups working on synthetic organic chemistry and medicinal chemistry, where a stable arylsulfonamide starting point shortens a synthetic sequence. Its tolerance of ordinary bench storage suits facilities that do not maintain dedicated inert-atmosphere handling for every reagent, and its solid form makes it practical for small-scale exploratory reactions as well as for repeated use across a series of derivatisation experiments.

Laboratory Applications

Medicinal chemistry fragment work — the sulfonamide motif forms strong hydrogen bonds and interacts with protein metal centres, making this a ready-made binding fragment for molecular design programmes.
Enzyme inhibitor studies — the pre-formed arylsulfonamide framework lets researchers investigate inhibitor structures without first having to construct the sulfonamide group themselves.
Synthesis of N-substituted derivatives — the acidic NH₂ group can be deprotonated and then alkylated or acylated, giving convenient access to a family of related compounds.
Catalytic coupling chemistry — the deprotonated sulfonamide nitrogen serves as a coupling partner for arylation, allowing N-aryl sulfonamides to be assembled from a stable, easily weighed solid.
Functional compound and material development — the para-ethyl group adds lipophilic character, which is useful when the physical properties of a target structure need to be adjusted.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS number: 138-38-5
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Catalogue number: E0773
Physical form: solid, stable under ordinary storage conditions
Pack sizes: available in standard TCI catalogue pack sizes; please refer to the ordering options on this page

Handling and Storage

Store the container tightly closed in a cool, dry place away from direct sunlight and sources of ignition, on a chemical shelf reserved for organic solids. The original supplier container is suitable for long-term storage; if the material is transferred, use a clean, dry, tightly sealing glass or chemically compatible plastic container with a clear label showing the compound name and CAS number. Unlike moisture-sensitive sulfonyl chlorides, this sulfonamide does not require an inert atmosphere. Handle it with standard laboratory practice: wear safety glasses, gloves, and a lab coat, weigh the solid in a way that limits dust formation, work in a fume hood when generating dust or preparing solutions, and keep the spatula and weighing vessel dry to avoid contaminating the stock. Consult the supplier safety data sheet before first use.