TCI E0897 Etomidate is an imidazole-derived compound in the form of a chiral carboxylate ester, widely known in the pharmacological literature as a rapid-onset hypnotic agent. In this catalogue the material is supplied as a pharmaceutical research reagent intended for laboratory experimental purposes only, not for human use or clinical practice. Its role in the laboratory is that of a comparison compound, an analytical standard, and a mechanistic probe, particularly in studies involving GABA type A receptors and in research on steroid biosynthesis pathways, since etomidate is also known to inhibit the enzyme 11β-hydroxylase.
The properties that make this compound a preferred choice are its well-characterised chemical identity and its activity profile, which is extensively documented in the scientific literature, allowing experimental results to be compared against previously published data. As a solid, the compound is easy to weigh accurately for the preparation of stock solutions, and its solubility in organic solvents such as dimethyl sulfoxide simplifies the preparation of dilution series for both cell-based assays and enzyme assays. This combination of reliable identity and practical handling behaviour supports reproducible work across repeated experimental runs.
The availability of milligram-scale packaging suits research requirements closely, because pharmacological experiments typically consume only small quantities per assay. In Indonesian laboratories, this format fits the working patterns of university pharmacology and biochemistry groups, hospital-affiliated research units, and institutional research centres that run receptor and enzyme studies on a project basis. Smaller pack sizes also reduce the amount of unused material held in storage between projects, which is a practical consideration for laboratories managing controlled-access reagent inventories.
- GABA type A receptor mechanism studies — etomidate is a documented modulator at this receptor, making it a suitable pharmacological tool for probing receptor behaviour under defined experimental conditions.
- Steroid biosynthesis pathway research — its known inhibition of 11β-hydroxylase allows investigators to interrupt the pathway deliberately and observe downstream effects in enzyme-based experimental systems.
- Analytical standard preparation — the well-characterised chemical identity of this material supports its use as a reference substance when establishing or verifying analytical methods in the laboratory.
- Comparison compound in pharmacological screening — extensive literature documentation lets researchers benchmark newly investigated compounds against a substance with a widely published activity profile.
- Enzyme and cell-based assay work — good solubility in organic solvents such as dimethyl sulfoxide makes it straightforward to prepare accurate dilution series for concentration-response experiments.
| Brand | TCI |
|---|---|
| CAS number | 33125-97-2 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use) |
| Pack sizes | available in milligram-scale research packaging |
| Physical form | solid |
| Storage | store according to the manufacturer's stated conditions on the product label |
Store the container in a cool, dry place away from direct sunlight, heat sources, and moisture, following the storage conditions stated by the manufacturer on the product label. Keep the material in its original tightly closed container, or in a clean, chemically compatible vial that is clearly labelled with the substance name and CAS number. Handle the solid in a well-ventilated area or fume hood using gloves, safety glasses, and a laboratory coat, and avoid generating or inhaling dust during weighing. Because this material is intended for experimental laboratory use only and not for human or clinical use, it should be stored in a controlled-access area, with usage recorded and any waste disposed of in accordance with institutional chemical waste procedures.
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