Elacridar TCI E1371

Chemical Identity

Other names: N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide
CAS No.: 143664-11-3
PubChem: CID 119373·SID 468591739
Formula: C34H33N3O5
Molecular weight: 563.65 g/mol
Purity: >98.0%(HPLC)
Storage: <0°C
Reference databases: ChemSpider

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide
SMILES: COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC
InChIKey: OSFCMRGOZNQUSW-UHFFFAOYSA-N
MDL: MDL00912604

Rp 3.975.300,00

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Elacridar, with CAS number 143664-11-3, is a chemical compound widely used in cancer research and cell biology. It functions as a modulator of P-glycoprotein (P-gp), a key transporter protein involved in the efflux of drugs from cells. In laboratory settings, Elacridar plays a crucial role in studying drug resistance mechanisms in cancer cells and assessing the effectiveness of therapeutic agents in the presence of P-gp. Its significance extends to pharmacological research, where it helps in understanding how drugs interact with cellular transport systems.

Elacridar is chemically stable and soluble in organic solvents, making it a preferred choice for various research methods. These properties allow it to be easily incorporated into in vitro and in vivo experiments. Its ability to inhibit P-gp activity makes it an essential tool for evaluating drug efficacy and resistance. Researchers rely on its consistent performance and compatibility with different experimental protocols, ensuring reliable and reproducible results.

In Indonesian laboratories, Elacridar is commonly used in cancer-related research, particularly in investigating how cancer cells develop resistance to chemotherapy. It is also integral to the development of more effective and efficient drugs. Its application supports both basic research and translational studies, contributing to advancements in oncology and pharmacology.

Related TCI products

Drug resistance mechanism studies in cancer cells, as Elacridar modulates P-glycoprotein activity, helping researchers understand how cancer cells resist therapeutic agents.
Evaluation of drug efficacy in the presence of P-gp, allowing scientists to assess how drugs are transported and retained within cells.
In vitro and in vivo experiments, due to its solubility in organic solvents and chemical stability, making it suitable for a wide range of experimental setups.
Pharmacological research on drug interactions with cellular transport systems, providing insights into drug metabolism and distribution.
Development of new and more effective cancer therapies, as Elacridar aids in identifying compounds that can overcome resistance mechanisms.

Brand	TCI
CAS number	143664-11-3
Molecular formula	—
Purity	—
Category	Life Science > Cell Biology > Cancer Research
Pack sizes	—
Physical form	—
Storage	Store in a cool, dry place away from light

Elacridar should be stored in a cool, dry place away from direct light to maintain its chemical stability. It is recommended to use airtight containers to prevent contamination and degradation. Due to its solubility in organic solvents, it should be handled with care to avoid exposure to incompatible substances. Laboratory personnel should wear appropriate personal protective equipment, such as gloves and safety goggles, when handling the compound. Proper ventilation should be ensured in the workspace to minimize inhalation risks. Regular monitoring of storage conditions is advised to ensure the integrity of the material remains intact for research use.

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