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Description
Erlotinib is a tyrosine kinase inhibitor compound that targets the epidermal growth factor receptor, commonly abbreviated as EGFR. As a research reagent, this compound is widely used in cell biology and molecular oncology laboratories to examine the role of EGFR signalling pathways in cell growth, division, and survival. Its function is to provide a well-characterised inhibitor that allows researchers to switch off a specific signalling pathway in a controlled manner, and then observe the resulting changes in cell behaviour, protein expression, and response to other treatments applied in the same experimental system.
The properties that make this compound a preferred choice are the selectivity of its action on the EGFR kinase domain together with the wealth of comparative data available in the published literature, so that experimental results can be interpreted against a strong body of reference material. The compound works by competing at the ATP binding site within the kinase domain, so that downstream phosphorylation is halted. In physicochemical terms, erlotinib is a solid with low water solubility, which means stock solutions are generally prepared using dimethyl sulfoxide before being diluted into culture media.
In Indonesian laboratories this reagent is typically handled within cell biology, molecular oncology, and pharmaceutical research groups working on signalling pathway studies at university and institutional research facilities. The 1 g pack provides sufficient material for a long series of cell-based experiments as well as for the preparation of standard solutions in analytical work, which suits laboratories that run extended experimental programmes and prefer to keep a single well-characterised lot in use across related studies.
Laboratory Applications
EGFR signalling pathway studies: the compound provides a controlled means of shutting down receptor activity so that downstream events can be attributed to that pathway specifically.
Molecular oncology research: its well-documented selectivity for the EGFR kinase domain allows researchers to probe how growth signalling contributes to proliferation in cultured tumour cell models.
Cell proliferation and survival assays: adding the inhibitor to culture media lets investigators measure changes in growth and viability that follow interruption of EGFR-mediated signalling.
Protein expression and phosphorylation analysis: because the compound halts downstream phosphorylation, it serves as a reference treatment when examining changes in protein expression by immunological methods.
Combination treatment experiments: the inhibitor is used alongside other interventions to observe how cells respond when one signalling route is blocked while a second treatment is applied.
Specifications
Brand: TCI, catalogue number E1529
CAS number: 183321-74-6
Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
Pack size: 1 g
Physical form: solid, with low water solubility
Storage: keep in a closed container under the conditions stated on the manufacturer label
Handling and Storage
Store the container tightly closed in a dry place, protected from light and moisture, and follow the storage conditions printed on the manufacturer label for this catalogue item. Keep the material in its original container or in a chemically compatible, well-sealed vessel that is clearly labelled with the compound name and CAS number. Because stock solutions are normally prepared in dimethyl sulfoxide, prepare and handle them in a fume hood using gloves, safety glasses, and a laboratory coat. This item is intended for experimental use only and must be handled by trained laboratory personnel following institutional chemical safety procedures. Avoid generating dust when weighing the solid, and record the date of stock solution preparation for traceability.
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