N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-valine TCI F0610

Name: TCI F0610 84624-17-9 N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-valine
Brand: TCI
SKU: TCI2510F061030508
Price: 1888950.0 IDR
Availability: InStock

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Berat 5g 25g

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Description

TCI F0610, with CAS number 84624-17-9, is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-valine — a D-configured valine whose amino group has been protected with an Fmoc group. This material is a standard building block for solid-phase peptide synthesis and is used whenever a peptide design calls for a valine residue with inverted stereochemistry. Its role in the laboratory is to supply a protected amino acid that is ready to be activated and coupled, so that a peptide chain can be built up step by step with full control over the sequence and the stereochemistry of every residue inserted.

The defining property of this material is its branched, hydrophobic isopropyl side chain. Branching at the beta carbon creates appreciable steric hindrance, so valine residues often require longer coupling times or more powerful activating reagents than straight-chain amino acids. This is precisely the property researchers exploit, because valine is known to favour beta-sheet formation and to increase the conformational rigidity of a peptide. Its aliphatic side chain requires no additional protecting group, while the Fmoc group can still be removed under basic conditions.

In Indonesian laboratories, this material is used in the same context as elsewhere: peptide chemistry and chemical biology work where a protected amino acid is assembled residue by residue on a solid support. It belongs to the Chemistry > Chemical Biology > Peptide Chemistry category and is handled by research groups and analytical laboratories that carry out stepwise synthesis and need reliable control over sequence and stereochemistry in each coupling cycle.

Laboratory Applications

Solid-phase peptide synthesis: serves as a ready-to-activate protected building block that is coupled onto the growing chain on resin, one residue at a time.
Incorporation of D-valine residues: provides the inverted stereochemistry required whenever a peptide design specifies a valine residue that is not in the natural L configuration.
Beta-sheet structural studies: the branched valine side chain favours beta-sheet formation, making this residue useful when a defined secondary structure is the target.
Conformationally rigid peptide design: valine increases the conformational rigidity of a peptide chain, so this block is chosen when restricted backbone flexibility is desired.
Fmoc-strategy chain assembly: the base-removable Fmoc group allows deprotection between cycles while the aliphatic side chain needs no additional protecting group at all.

Specifications

Brand: TCI
CAS number: 84624-17-9
Chemical name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-valine
Category: Chemistry > Chemical Biology > Peptide Chemistry
Pack sizes: available in the pack sizes offered by TCI for this catalogue item
Storage: store according to the manufacturer's instructions on the product label

Handling and Storage

Store this material in its original tightly closed container, kept dry and protected from moisture and direct light, and follow the storage conditions stated on the manufacturer's label and safety data sheet. Use clean, dry glassware and spatulas when weighing, and allow a cold container to reach room temperature before opening to reduce moisture uptake. Handle the solid in a well-ventilated area or fume hood, wearing a laboratory coat, gloves, and eye protection. Avoid generating dust, close the container immediately after use, and keep it separated from incompatible reagents. Consult the safety data sheet before first use and dispose of residues in accordance with local laboratory waste procedures.