Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-Nepsilon-tetradecanoyl-L-lysine TCI F1143

Chemical Identity

Other names: Nalpha-Fmoc-Nepsilon-tetradecanoyl-L-lysine · Fmoc-Lys(myristoyl)-OH · Fmoc-Lys(Myr)-OH
CAS No.: 1128181-23-6
PubChem: CID 25231984·SID 354334232
Formula: C35H50N2O5
Molecular weight: 578.79 g/mol
Purity: >98.0%(HPLC)(N)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-(tetradecanoylamino)hexanoic acid
SMILES: CCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
InChIKey: PNXSYZSEFDFTDZ-YTTGMZPUSA-N

Rp 4.611.600,00

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TCI F1143, with the CAS number 1128181-23-6, is a specialized chemical compound used in chemical biology, particularly in peptide chemistry. This compound is a derivative of L-lysine, modified with a tetradecanoyl group and a fluoren-9-ylmethoxykarbonyl group, making it a valuable reagent for synthesizing complex peptides. In laboratory settings, it serves as a key building block for creating bioactive molecules with specific functional properties. Its role extends to applications in drug development and biomarker research, where precise chemical structures are essential.

The compound is favored for its stable chemical structure and its ability to participate in various reactive groups, enabling efficient coupling reactions. Its solubility in organic solvents simplifies synthesis and processing steps, making it a preferred choice for researchers working on peptide-based compounds. The molecule’s specificity and reactivity make it ideal for applications requiring high precision and controlled chemical interactions. This reliability ensures consistent results in both academic and industrial research environments.

In Indonesian laboratories, TCI F1143 is commonly used in scientific research, especially in pharmaceutical, biotechnology, and medicinal chemistry fields. It supports the development of new bioactive compounds with targeted biological functions. Its application in these areas highlights its importance in advancing research that leads to the creation of innovative therapeutic agents and diagnostic tools. The compound’s versatility and effectiveness make it a staple in modern laboratory practices.

Advantages (TCI brochure)

Building block for optimizing pharmacokinetics of peptides

TCI brochures (PDF)

Human-Serum-Albumin Binding Agents for Improvement of Pharmacokinetics 2019-02-22 · p. 1
Amino Acids and Peptide Synthesis Reagents 2025-08-14 · p. 22

Related TCI products

Peptide Synthesis: TCI F1143 is ideal for constructing complex peptides due to its reactive groups and stable structure, enabling precise molecular assembly.
Drug Development: Its ability to form bioactive molecules makes it a key component in the creation of new therapeutic agents with specific biological activities.
Biomarker Research: The compound supports the synthesis of biomarkers, aiding in the identification and analysis of biological processes in medical studies.
Medicinal Chemistry: Its chemical properties allow for the design of compounds with tailored pharmacological effects, enhancing research in drug discovery.
Bioconjugation Studies: The reactive groups in TCI F1143 facilitate the attachment of functional moieties, making it useful for conjugation experiments in biotechnology.

From the TCI brochure

Building block for peptides with short blood half-life

Brand	TCI
CAS number	1128181-23-6
Molecular formula	—
Purity	—
Category	Chemistry > Chemical Biology > Peptide Chemistry
Pack sizes	—
Physical form	—
Storage	Store in a cool, dry place away from light

TCI F1143 should be stored in a cool, dry environment, away from direct light and sources of heat to maintain its chemical stability. It is recommended to use airtight containers to prevent moisture absorption and contamination. As a chemical reagent, it should be handled with appropriate personal protective equipment, such as gloves and safety goggles, to ensure laboratory safety. While no specific hazards are mentioned, standard chemical handling procedures should be followed. The compound is typically used in controlled laboratory settings, and its storage conditions should align with general chemical safety guidelines to ensure optimal performance and safety during experimentation.

References cited in the TCI brochure

P Kurtzhals. Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo Biochemical Journal, 1995. doi:10.1042/bj3120725
Batya Plotkin. Insulin Mimetic Action of Synthetic Phosphorylated Peptide Inhibitors of Glycogen Synthase Kinase-3 The Journal of Pharmacology and Experimental Therapeutics, 2003. doi:10.1124/jpet.102.047381
Ib Jonassen. Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin Pharmaceutical Research, 2012. doi:10.1007/s11095-012-0739-z
Yuanyan Tan. Myristic acid-modified thymopentin for enhanced plasma stability and immune-modulating activity International Immunopharmacology, 2017. doi:10.1016/j.intimp.2017.03.025