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Description
TCI G0171 Guanosine is a purine nucleoside composed of the base guanine linked to a ribose sugar, supplied as a white crystalline powder. It is one of the fundamental building blocks of RNA and serves as the starting point for the preparation of important nucleotides such as GMP, GDP, and GTP. In life science laboratories, guanosine plays a dual role: it acts as a raw material for the chemical synthesis of nucleotides and oligonucleotides, and at the same time serves as a test molecule in studies of cell signalling, purine metabolism, and the interaction of nucleic acids with proteins and drugs.
The most notable characteristic of guanosine is its ability to form highly directional hydrogen bonds through the guanine base, which allows the formation of ordered structures such as G-quartets and supramolecular gels. This property has made it a favoured material in supramolecular chemistry and soft matter research. From a practical handling standpoint, its solubility in water is relatively limited, so it is often dissolved with the help of gentle warming, pH adjustment, or polar solvents such as dimethyl sulfoxide. Its stability in the dry solid form is good, so the material can be stored for a considerable period when protected from moisture.
Laboratories in Indonesia typically use guanosine of this grade in academic research groups, biochemistry and molecular biology teaching laboratories, and analytical or formulation development units. It is commonly drawn on as a reference substance in nucleic acid work, as a synthetic intermediate in nucleotide preparation, and as a model compound in metabolism and cell signalling studies, where a consistent, well-characterised crystalline powder is needed for reproducible experimental results.
Laboratory Applications
- Nucleotide synthesis — guanosine serves as the direct chemical precursor for preparing GMP, GDP, and GTP, giving synthetic chemists a defined starting material with the guanine base and ribose sugar already assembled.
- Oligonucleotide preparation — as a basic RNA building block, it supplies the guanosine unit required in the chemical assembly of oligonucleotide sequences for molecular biology and structural studies.
- Cell signalling research — the compound is widely used as a test molecule when investigating signalling pathways, since guanosine-derived nucleotides are central mediators in many intracellular communication processes.
- Purine metabolism studies — guanosine functions as a defined substrate and reference compound in experiments tracing purine metabolic routes, enzyme activity, and related biochemical conversions in cells.
- Supramolecular chemistry and soft materials — the highly directional hydrogen bonding of the guanine base enables formation of G-quartets and supramolecular gels, making it a favoured material for soft matter research.
Specifications
- Brand: TCI
- CAS number: 118-00-3
- Product code: G0171
- Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
- Physical form: white crystalline powder
- Storage: keep in the dry solid form, protected from moisture; stability in this state is good over extended periods
Handling and Storage
Store TCI G0171 Guanosine in a tightly closed container, kept dry and protected from moisture, since the compound remains stable over long periods in its dry solid state. Original supplier containers or well-sealed glass or chemically resistant plastic bottles are suitable; secondary containment in a desiccated cabinet gives added protection in humid Indonesian laboratory conditions. Handle the powder in a well-ventilated area or fume hood to avoid dust generation, and wear standard laboratory personal protective equipment including a lab coat, safety glasses, and gloves. When preparing solutions, note that aqueous solubility is limited, so gentle warming, pH adjustment, or polar solvents such as dimethyl sulfoxide may be required. Use clean, dry spatulas and weighing vessels to prevent contamination, close containers promptly after use, and follow institutional procedures for chemical waste disposal.
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