Lomefloxacin Hydrochloride TCI L0216

TCI L0216 Lomefloxacin Hydrochloride is the hydrochloride salt of lomefloxacin, a fluoroquinolone-class antibiotic distinguished by the two fluorine atoms on its quinolone framework. In the laboratory, this compound is used primarily as a test and reference substance in microbiological research rather than for direct application in humans. Researchers rely on it to assess bacterial susceptibility, to study the mechanisms by which antibiotics act, and to examine the development of resistance, which has become one of the central concerns in both public health and modern pharmaceutical research.

The property that makes this material genuinely useful is its clearly defined mechanism of action: inhibition of DNA gyrase and topoisomerase IV, the enzymes bacteria require in order to replicate their genetic material. Because this mechanism is so well characterised, the compound serves as a dependable tool in experiments that call for directed selective pressure. The hydrochloride salt form improves solubility in aqueous media compared with the free base, which makes the preparation of stock solutions for disc diffusion assays, broth dilution testing and instrumental analysis considerably more practical. The fluoroquinolone framework additionally confers ultraviolet absorption characteristics useful in analytical work.

In Indonesian laboratories, materials of this type are typically found in university microbiology departments, pharmaceutical quality control units, and research institutes working on antimicrobial susceptibility and resistance surveillance. It is generally held in small quantities as a reference standard, weighed out for stock solution preparation as individual assays require, and handled within the ordinary reagent-management practices of a laboratory that runs both routine susceptibility testing and method development work.

• Antimicrobial susceptibility testing — the compound serves as a defined fluoroquinolone challenge agent, allowing bacterial isolates to be assessed against a substance whose inhibitory target is fully characterised.
• Broth dilution assays — improved aqueous solubility of the hydrochloride salt permits accurate serial dilution series to be prepared in liquid media without solubility artefacts distorting endpoint readings.
• Disc diffusion studies — stock solutions prepared from this salt can be loaded onto discs reproducibly, supporting consistent zone measurement across repeated experimental runs and comparison batches.
• Antibiotic resistance research — the well-defined action on DNA gyrase and topoisomerase IV makes it suitable for imposing directed selective pressure when studying how bacterial resistance emerges.
• Instrumental analysis and method development — the fluoroquinolone framework provides ultraviolet absorption characteristics that support detection and quantification in chromatographic and spectrophotometric procedures.

• Catalogue number: L0216

Store the material in its original tightly closed container, kept in a cool, dry and well-ventilated place away from direct sunlight, moisture and incompatible substances, following the conditions specified on the manufacturer's label and safety data sheet. Amber glass or the supplied original packaging is appropriate for protecting the compound from light. Handle in a well-ventilated area or fume hood, wearing a laboratory coat, gloves and eye protection, and avoid generating dust or inhaling the powder. Prepared stock solutions should be clearly labelled with concentration and preparation date. As this is an antibiotic intended for research use only, dispose of residues and contaminated consumables through the laboratory's designated chemical and biological waste channels rather than general waste.

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