TCI M0285 is 2-Methylthiazoline, a five-membered heterocyclic compound containing both a sulfur atom and a nitrogen atom within a single ring, bearing a methyl group at the second position. As a heterocyclic building block, this compound is widely used in organic synthesis to introduce the thiazoline scaffold into target molecules. The thiazoline framework itself appears in a range of bioactive molecules and natural products, so having it available as a ready-to-use reagent shortens synthetic routes that would otherwise have to begin with stepwise construction of the ring.
The property that makes this compound a preferred choice is the reactivity of the C=N bond within its ring combined with the presence of the sulfur atom. That cyclic imine bond can undergo nucleophilic attack, opening the way to transformations into amide, amine, and other heterocyclic derivatives. At the same time, the pairing of nitrogen and sulfur atoms makes this ring an attractive ligand in coordination chemistry, since both are capable of binding to metal centres. The methyl group at position two also supplies hydrogens that can be deprotonated for carbon-carbon bond forming reactions under suitably basic conditions.
In Indonesian laboratories, this reagent is typically encountered in synthetic organic chemistry and medicinal chemistry research groups at universities and research institutes, as well as in development work where a thiazoline-containing intermediate is required. It is generally used at bench scale for route exploration, derivative preparation, and ligand synthesis, where sourcing a defined heterocyclic building block is more practical than preparing the ring in-house.
Related TCI products
- TCI A0336 6142-15-0 2-Amino-4-methylthiazole Hydrochloride
- TCI A3264 29926-41-8 2-Acetyl-2-thiazoline
- TCI A3066 82632-77-7 2-Amino-4-(4-chlorophenyl)-5-methylthiazole
- TCI A2887 30748-47-1 5-Acetyl-2-amino-4-methylthiazole
- TCI A1303 1603-91-4 2-Amino-4-methylthiazole
- TCI A1250 7305-71-7 2-Amino-5-methylthiazole
- Heterocyclic scaffold introduction: the thiazoline ring is already assembled, so synthetic routes toward thiazoline-containing targets can begin from this reagent rather than from stepwise ring formation.
- Nucleophilic addition chemistry: the cyclic C=N bond is susceptible to nucleophilic attack, making this compound a convenient entry point to amide, amine, and related derivative classes.
- Ligand preparation for coordination chemistry: the adjacent nitrogen and sulfur atoms can both bind metal centres, so the ring serves as a useful donor framework in complex synthesis.
- Carbon-carbon bond formation: the methyl group at position two carries hydrogens that can be deprotonated under appropriately basic conditions to generate a nucleophilic carbon for coupling.
- Medicinal chemistry and natural product work: because thiazoline motifs occur in bioactive molecules and natural products, this building block supports analogue preparation and structure-activity exploration.
| Brand | TCI |
|---|---|
| CAS number | 2346-00-1 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Heterocyclic Building Blocks |
| Pack sizes | available in standard TCI catalogue pack sizes; please confirm the packaging option when ordering |
| Physical form | — |
| Storage | store according to the conditions stated on the manufacturer label and accompanying documentation |
- Chemical name: 2-Methylthiazoline
Store this reagent in its original tightly closed container, kept in a cool, dry, and well-ventilated area away from heat sources, ignition sources, and incompatible materials such as strong oxidising agents and strong acids. Follow the storage temperature stated on the manufacturer label. Handle the material inside a fume hood using appropriate personal protective equipment, including safety glasses, chemical-resistant gloves, and a laboratory coat. Keep the container closed when not in use to limit exposure to air and moisture, transfer with clean dry glassware, and consult the supplied Safety Data Sheet before use, first aid, and waste disposal.
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