TCI M1117 is 4-Methylcyclohexylamine supplied as a mixture of cis and trans isomers. It is a cyclic aliphatic primary amine carrying a methyl group at the para position relative to the amino group. The compound belongs to the non-heterocyclic building block family and is widely used to introduce a substituted cyclohexyl fragment into target molecules. In the laboratory, this amine acts as a nucleophile in the formation of amides, sulfonamides, ureas, and imines, and also serves as an organic base in certain reactions. The cyclohexyl fragment it carries contributes lipophilic character and a three-dimensional spatial shape that differs from a flat aromatic ring.
The properties that make this material a preferred choice originate from its reactive and relatively unhindered primary amino group, which reacts readily with acid chlorides, anhydrides, isocyanates, and carbonyl compounds. The cyclohexane ring provides a saturated framework that is rigid yet still able to change conformation, while the methyl group at the four position adds lipophilic weight without introducing a new functional group that would require protection. Supply as a cis and trans mixture is in fact an advantage at the exploratory stage, because researchers can evaluate the influence of the substituted cyclohexyl fragment before committing to a single isomer.
In Indonesian laboratories, this building block is typically used in organic synthesis groups at universities and research institutes, as well as in formulation and process development work where a saturated amine fragment is needed. It is commonly drawn upon for small-scale route scouting, derivative preparation, and reference sample synthesis, where a straightforward primary amine reagent allows a synthetic sequence to proceed without additional protecting group strategies.
Related TCI products
- TCI M2105 6850-35-7 3-Methylcyclohexylamine (cis- and trans- mixture)
- TCI M1780 2523-55-9 trans-4-Methylcyclohexylamine
- TCI M1422 6864-37-5 4,4'-Methylenebis(2-methylcyclohexylamine) (mixture of isomers)
- TCI M0896 7003-32-9 2-Methylcyclohexylamine (cis- and trans- mixture)
- TCI B4014 37942-69-1 4-Butylcyclohexylamine (cis- and trans- mixture)
- TCI B4004 25834-93-9 4-sec-Butylcyclohexylamine (cis- and trans- mixture)
- Amide bond formation: the unhindered primary amino group couples efficiently with acid chlorides, anhydrides, and activated carboxylic acids to give substituted cyclohexyl amides.
- Urea synthesis: reaction with isocyanates proceeds directly at the amino group, making this amine a convenient partner for preparing cyclohexyl-substituted urea derivatives in exploratory work.
- Sulfonamide preparation: the primary amine reacts cleanly with sulfonyl chlorides, allowing researchers to install a saturated, lipophilic cyclohexyl group onto a sulfonamide scaffold.
- Imine and reductive amination chemistry: condensation with aldehydes and ketones forms imines that can be carried forward, introducing the methylcyclohexyl fragment into larger target structures.
- Building block for three-dimensional scaffolds: the saturated ring offers spatial geometry unlike flat aromatic rings, useful when exploring conformational and lipophilicity effects in molecular design.
| Brand | TCI |
|---|---|
| CAS number | 6321-23-9 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | available in standard TCI catalogue pack sizes; please confirm the required quantity when ordering |
| Physical form | — |
| Storage | keep tightly closed in a cool, well ventilated area, following the manufacturer's instructions on the product label |
- Chemical form: mixture of cis and trans isomers
Store the container tightly closed in a cool, dry, and well ventilated place, away from heat sources, open flame, and direct sunlight. Keep the material separated from acids, oxidising agents, and carbonyl compounds with which the amine can react. Use the original manufacturer's container or a chemically compatible, clearly labelled alternative, and close it immediately after each use to limit exposure to air and moisture. Handle the compound in a fume hood while wearing safety glasses, chemical resistant gloves, and a laboratory coat. Avoid inhaling vapours and prevent contact with skin and eyes. Always refer to the manufacturer's safety data sheet before use, and follow your institution's procedures for chemical waste disposal.
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