19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoic Acid TCI M2666

19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoic Acid is a specialized chemical compound used in biochemical and biomedical research. This compound contains a polyethylene glycol (PEG) chain and a maleimide group, making it a key reagent in PEGylation processes. In laboratory settings, it plays a crucial role in modifying biological molecules by attaching PEG chains, which enhances the stability, solubility, and reduces immunogenicity of the target molecules. Its versatility makes it an essential tool for researchers working on drug development and molecular engineering.

The compound is valued for its high reactivity, particularly at the maleimide group, which allows for the formation of covalent bonds with various biomolecules such as proteins, peptides, and lipids. This reactivity ensures efficient conjugation reactions, making it a preferred choice in applications requiring precise molecular modifications. Additionally, its structural complexity and functional groups enable it to be tailored for specific research needs, contributing to its widespread use in both academic and industrial laboratories.

In Indonesian laboratories, this compound is commonly used in applied research projects such as vaccine development, biopharmaceuticals, and molecular modification for medical applications. Many research institutions and universities rely on it to advance their studies in biochemistry and biotechnology. Its reliability and effectiveness make it a standard reagent in experimental workflows across various scientific disciplines.

• PEGylation of Proteins: This compound is ideal for attaching PEG chains to proteins, enhancing their solubility and reducing immunogenicity, which is crucial for drug development.
• Peptide Conjugation: The maleimide group allows for efficient covalent bonding with peptides, making it suitable for creating modified peptides for therapeutic or diagnostic applications.
• Lipid Modification: It is used to modify lipid structures, enabling the development of more stable and bioavailable lipid-based drug delivery systems.
• Vaccine Formulation: The compound aids in the modification of vaccine components, improving their stability and immunogenic profile for better therapeutic outcomes.
• Molecular Imaging Studies: Its ability to form covalent bonds with biomolecules makes it useful in creating targeted imaging agents for diagnostic purposes.

This compound should be stored in a cool, dry environment, away from direct sunlight and sources of heat. It is recommended to use airtight containers to prevent moisture absorption and contamination. Due to its reactivity, it should be handled with appropriate personal protective equipment, including gloves and safety goggles. Storage conditions should maintain a stable temperature to preserve its chemical integrity. In laboratory settings, it is important to ensure that the compound is kept in a secure location to prevent accidental exposure. Proper labeling and documentation are essential for safe handling and compliance with laboratory safety protocols.

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