TCI M3891 7-Methoxynaphthalen-2-ol is a naphthalene derivative carrying a hydroxyl group at the two position and a methoxy group at the seven position. The compound is essentially the monomethyl ether of naphthalene-2,7-diol, which means it presents one reactive phenol group alongside one stable aromatic ether within the same molecule. In the laboratory this material serves as a bicyclic aromatic building block, useful for constructing target molecules built on a naphthalene framework in both medicinal chemistry research and the development of functional materials and organic dyes.
The characteristic that makes this compound a preferred choice is the desymmetrisation already built into the molecule. Because only one of the two oxygen substituents remains as a free phenol, researchers can perform alkylation, acylation, triflation, or cross-coupling selectively at that position without needing an additional protecting group strategy. The electron-rich naphthalene ring provides a planar, rigid scaffold with ultraviolet absorption and fluorescence behaviour that is attractive for optical applications. The free phenol also allows formation of the corresponding triflate as a palladium-catalysed cross-coupling partner, opening a route toward biaryl derivatives and related extended systems.
In Indonesian laboratories this type of building block is typically used in university and institutional synthetic chemistry groups working on medicinal chemistry targets, as well as in research on functional organic materials and dye chemistry. It is normally handled at bench scale within fume-hood synthesis work, where a defined naphthalene core saves several preparative steps. Research teams generally order it as a supporting reagent for multi-step synthesis programmes rather than as a routine bulk consumable.
- Medicinal chemistry scaffold synthesis: the rigid bicyclic naphthalene core serves as a starting framework for building target molecules, letting chemists elaborate substituents while retaining a defined aromatic backbone.
- Selective O-functionalisation studies: with only one free phenol available, alkylation and acylation can be directed to a single site without additional protecting group manipulation, simplifying multi-step synthetic routes considerably.
- Palladium-catalysed cross-coupling work: conversion of the phenol into the corresponding aryl triflate produces a competent coupling partner for constructing biaryl and extended aromatic derivatives in research settings.
- Functional organic materials development: the electron-rich, planar naphthalene ring with its ultraviolet absorption and fluorescence behaviour makes the compound useful in the preparation of optically active molecular systems.
- Organic dye chemistry research: the naphthalene framework bearing complementary hydroxyl and methoxy substituents provides a classic intermediate platform for preparing coloured aromatic compounds and related chromophore structures.
| Brand | TCI (Tokyo Chemical Industry) |
|---|---|
| CAS number | 5060-82-2 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | available in standard TCI research catalogue pack sizes; please confirm the currently listed packaging option when ordering |
| Physical form | — |
| Storage | keep in the original tightly closed container, protected from light, in a cool and well-ventilated place |
- Chemical name: 7-Methoxynaphthalen-2-ol
Store the container tightly closed in a cool, dry, well-ventilated area away from direct sunlight and sources of ignition, keeping it separate from strong oxidising agents. As a phenolic aromatic solid, the material should be kept in its original amber or opaque container to limit light exposure and reduce the risk of gradual discolouration. Handle all weighing and transfer operations inside a functioning fume hood, wearing safety goggles, nitrile gloves, and a laboratory coat. Avoid generating dust, avoid inhalation and skin contact, and wash hands thoroughly after handling. Consult the manufacturer's safety data sheet before first use and dispose of residues in accordance with institutional chemical waste procedures.
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