Piperaquine Tetraphosphate Tetrahydrate TCI P1987

Chemical Identity

CAS No.: 915967-82-7
PubChem: CID 53318025·SID 468592575
Formula: C29H44Cl2N6O16P4
Molecular weight: 927.5 g/mol
Purity: >98.0%(HPLC)(N)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline;phosphoric acid
SMILES: C1CN(CCN1CCCN2CCN(CC2)C3=C4C=CC(=CC4=NC=C3)Cl)C5=C6C=CC(=CC6=NC=C5)Cl.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O
InChIKey: OAKKJVUSSVZQRF-UHFFFAOYSA-N

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Berat 5g 25g

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Dokumen Keamanan & Mutu

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CoA (Certificate of Analysis)

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Piperaquine tetraphosphate tetrahydrate is the hydrated phosphate salt of piperaquine, a bisquinoline antimalarial compound. Piperaquine is widely known as the partner drug to dihydroartemisinin in artemisinin-based combination therapy. In the laboratory, this TCI product serves as a research reagent and is listed under the antibiotics/antimicrobials category in the TCI catalog. It is an important material for researchers studying antimalarial pharmacology and parasite resistance, and for those developing analytical methods for drug substances.

Researchers often choose piperaquine because of its long elimination half-life. This property makes it a good partner for artemisinin derivatives, which act quickly but only for a short time. The tetraphosphate tetrahydrate salt form is commonly used in pharmaceutical preparations, so this reagent is a useful comparison material that closely matches the form found in actual medicines. The 5 g and 25 g pack sizes are enough for method development, dissolution testing, and formulation experiments that need larger amounts of material.

Indonesia uses the dihydroartemisinin-piperaquine combination as one of its main malaria therapies. For this reason, the reagent is highly relevant to pharmaceutical laboratories, quality control and testing laboratories, and university research groups across Indonesia. Typical users include teams analyzing antimalarial drug products, academic groups investigating parasite resistance, and formulation scientists working on dosage forms. Having a consistent, catalog-grade reagent from TCI supports reproducible results across these research and testing activities.

TCI brochures (PDF)

Antimicrobials and Antitumor Agents for Research and Experimental Use 2025-04-24 · p. 11
Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 11

Related TCI products

Antimalarial pharmacology research: the compound lets researchers study how piperaquine behaves on its own and in combination with dihydroartemisinin under controlled laboratory conditions.
Parasite resistance studies: as a well-established partner drug in combination therapy, piperaquine is a relevant reagent for investigating how malaria parasites lose sensitivity to bisquinoline compounds.
Analytical method development: the salt form used in pharmaceutical preparations makes this reagent a suitable comparison material for developing and checking methods to analyze piperaquine-containing products.
Dissolution testing: because the tetraphosphate tetrahydrate form closely matches the form found in actual medicines, it suits dissolution studies that compare against finished dosage forms.
Formulation experiments: the larger 25 g pack provides enough material for formulation trials that use more substance than routine analytical work.

Brand	TCI (product code P1987)
CAS number	915967-82-7
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Antibiotics
Pack sizes	5 g and 25 g
Physical form	refer to the TCI product specification and certificate of analysis
Storage	follow the storage conditions on the TCI label and safety data sheet

Store piperaquine tetraphosphate tetrahydrate in its original, tightly closed container. Keep it in a cool, dry, well-ventilated area away from direct light and sources of moisture, and follow any specific temperature guidance on the TCI label or safety data sheet. Because this is a hydrated salt, reseal the container promptly after each use so the hydration state stays stable. Wear standard laboratory protective equipment, including gloves, safety glasses, and a lab coat. Weigh the powder in a way that keeps dust to a minimum, and avoid inhaling it or letting it touch your skin or eyes. Read the safety data sheet before use, and dispose of waste according to your institution's chemical waste rules and local regulations.

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