2,2,3,3-Tetrafluoro-1-propanol from TCI (product code T0101, CAS 76-37-9) is a fluorinated alcohol. It has a three-carbon chain with four fluorine atoms at positions two and three and a primary hydroxyl group at the end of the chain. In the laboratory it is classed as a fluorinated building block. Chemists use it to add fluoroalkyl fragments to target molecules by forming ethers, esters, carbonates or urethanes. Because its physicochemical behaviour differs from ordinary alcohols, it is also used as a specialty solvent.
Chemists choose this compound because the highly electronegative fluorine atoms change the character of the hydroxyl group in useful ways. Compared with ordinary propanol, the alcohol is more acidic and a stronger hydrogen-bond donor, but it is less nucleophilic. This combination lets it dissolve certain dyes and polymers that dissolve poorly in common solvents. Its derivatives carry the typical traits of fluorinated compounds: better chemical and oxidative stability, low surface energy, and changed lipophilicity. These traits matter in both medicinal chemistry and materials chemistry.
In Indonesia, 2,2,3,3-Tetrafluoro-1-propanol is relevant to organic chemistry, medicinal chemistry and materials research laboratories. University research groups, pharmaceutical development teams and polymer or coatings laboratories can use it for synthetic work where a fluoroalkyl group is needed. They can also use it as a solvent for hard-to-dissolve substances. Supplying a recognised brand such as TCI helps local laboratories get consistent quality from batch to batch for research and development.
TCI brochures (PDF)
- Fluorous Chemistry 2025-01-21 · p. 5
Related TCI products
- TCI T3493 69804-19-9 2,2,3,3-Tetrafluoro-3-[[1,1,1,2,3,3-hexafluoro-3-[(1,2,2-trifluorovinyl)oxy]propan-2-yl]oxy]propionitrile
- TCI T2323 652-32-4 2,3,5,6-Tetrafluoro-4-methylbenzoic Acid
- TCI T2296 425-61-6 2,2,3,3-Tetrafluoro-1,4-butanediol
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- TCI T1943 652-34-6 2,3,5,6-Tetrafluoro-4-hydroxybenzoic Acid
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- Fluoroalkyl ether synthesis: the primary hydroxyl group can be converted into ethers, so a tetrafluoropropyl fragment can be built into target molecules for structure–property studies.
- Ester and carbonate preparation: reacting the alcohol with acids, acid derivatives or carbonylating agents gives fluorinated esters and carbonates that carry the stability typical of fluorinated compounds.
- Urethane formation: the alcohol can react with isocyanates to form fluorinated urethanes, which are useful in materials research where low surface energy and chemical resistance are wanted.
- Medicinal chemistry modification: adding the fluoroalkyl fragment lets researchers change the lipophilicity and oxidative stability of candidate molecules during lead optimisation and structure–activity work.
- Specialty solvent use: its higher acidity and strong hydrogen-bond donation help it dissolve certain dyes and polymers that dissolve poorly in conventional laboratory solvents.
| Brand | TCI (product code T0101) |
|---|---|
| CAS number | 76-37-9 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Fluorinated Building Blocks |
| Pack sizes | see the current product listing for available pack sizes |
| Physical form | liquid |
| Storage | keep tightly closed in a cool, dry, well-ventilated place, following the supplier's Safety Data Sheet |
Store 2,2,3,3-Tetrafluoro-1-propanol in its original, tightly sealed container. Keep it in a cool, dry and well-ventilated area, away from heat, ignition sources, direct sunlight and incompatible materials such as strong oxidising agents. Use chemically resistant containers and keep labels legible. Handle the material in a fume hood and wear suitable gloves, safety goggles and a laboratory coat. Avoid inhaling vapours and avoid contact with skin and eyes. Read the TCI Safety Data Sheet before use, and dispose of waste according to local regulations and institutional laboratory procedures.
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![69804-19-9 2,2,3,3-Tetrafluoro-3-[[1,1,1,2,3,3-hexafluoro-3-[(1,2,2-trifluorovinyl)oxy]propan-2-yl]oxy]propionitrile - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510T3493_2f6bddec-1b38-407e-8eff-cb77397f9f37.jpg?v=1769058235&width=533)

