![TCI T3597 289706-46-3 4-[2,2,2-Trifluoro-1-[(trimethylsilyl)oxy]ethyl]morpholine](http://amiscientific.com/cdn/shop/files/TCI2510T3597_8f406d72-0f2e-4b57-8856-3e4ea687675b.jpg?v=1792664214&width=1946)
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4-[2,2,2-Trifluoro-1-[(trimethylsilyl)oxy]ethyl]morpholine (CAS 289706-46-3) is a high-quality chemical from TCI, supplied as GC Grade / for Synthesis.
Application: Used as a silylating reagent for hydroxyl-group protection and GC derivatisation.
Specifications:
- Molecular formula: C9H18F3NO2Si
- CAS number: 289706-46-3
- Purity: >95.0%(GC)
- TCI product code: T3597
Available from AMI Scientific, the authorised TCI distributor in Indonesia. Contact us for pricing and stock availability — we ship throughout Indonesia.
Advantages (TCI brochure)
- Air-stable liquid
- Usable as a trifluoromethyl anion equivalent for nucleophilic additions
- Applicable to cross coupling using copper catalyst
TCI brochures (PDF)
- Morpholine Derivative Usable for Trifluoromethylation 2019-08-09 · p. 1
- Trifluoromethylating Reagents 2024-08-27 · p. 3
- Please inquire for pricing and availability of listed products to our local sales representatives. Si Si Et 2026-07-16 · p. 12
- Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 9
Related TCI products
- TCI T1277 13368-42-8 N-(Trimethylsilyl)morpholine
- TCI T3272 181934-29-2 1-[(Trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one
- TCI T3190 130995-13-0 3-(Trimethylsilylethynyl)thiophene
- TCI T3189 40231-03-6 2-(Trimethylsilylethynyl)thiophene
- TCI T2590 113306-55-1 1-[2-(Trimethylsilyl)ethoxycarbonyloxy]benzotriazole
- TCI T2544 1001067-09-9 2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate
From the TCI brochure
- Nucleophilic addition to carbonyl compounds (R1 = aryl, heteroaryl; R2 = H, aryl, heteroaryl), catalytic CsF, DME, 80 °C
- Cross coupling with aryl iodides, catalytic CuI and 1,10-phenanthroline, CsF, diglyme, 80 °C
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Data from the TCI brochure
| Yield, nucleophilic addition (product with two phenyl groups, drawn) | Y. 75% (cat. CsF [C2204], DME, 80 °C) |
|---|---|
| Yield, nucleophilic addition (product with alkenyl and two phenyl groups, drawn) | Y. 70% (cat. CsF [C2204], DME, 80 °C) |
| Yield, nucleophilic addition (thienyl product, drawn) | Y. 80% (cat. CsF [C2204], DME, 80 °C) |
| Yield, cross coupling (nitro-aryl product, drawn) | Y. 77% (cat. CuI, cat. 1,10-phenanthroline, CsF, diglyme, 80 °C) |
| Yield, cross coupling (ethoxy-aryl product, drawn) | Y. 54% (cat. CuI, cat. 1,10-phenanthroline, CsF, diglyme, 80 °C) |
| Yield, cross coupling (methyl-thienyl product, drawn) | Y. 75% (cat. CuI, cat. 1,10-phenanthroline, CsF, diglyme, 80 °C) |
Source: TCI brochure RR121 (2019-08-09)
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References cited in the TCI brochure
- Hideaki Kondo. Copper‐Catalyzed Aromatic Trifluoromethylation via Group Transfer from Fluoral Derivatives Advanced Synthesis & Catalysis, 2011. doi:10.1002/adsc.201000825
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