2,2,2-Trifluoroethyl Triflate for 2,2,2-Trifluoroethyl Etherification
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2,2,2-Trifluoroethyl Triflate (CF3CH2OTf, TCI code T1604) is a reagent for introducing the 2,2,2-trifluoroethyl group through etherification. In the TCI practical example, it is used for the 2,2,2-trifluoroethyl etherification of 4'-hydroxyacetophenone. The hydroxyl group is first deprotonated with sodium hydride (60% dispersion in paraffin liquid) in DMF at room temperature for 10 minutes. 2,2,2-Trifluoroethyl Triflate is then added, and the mixture is stirred overnight at 60 °C. After washing with water and brine and purification by silica gel column chromatography, 4'-(2,2,2-trifluoroethoxy)acetophenone is obtained as a pale yellow solid in 71% yield. The reaction is monitored by UPLC, and the product is characterized by 1H NMR (270 MHz, CDCl3).
Related products
- TCI H0193 99-93-4 4'-Hydroxyacetophenone
- TCI T1604 6226-25-1 2,2,2-Trifluoroethyl Trifluoromethanesulfonate
- TCI S0481 7646-69-7 Sodium Hydride (60%, dispersion in Paraffin Liquid)
Source
- TCI Practical Example: www.tcichemicals.com/ID/en/product/tci-topics/TCIPracticalExample_20250113
- TCI product page H0193: tcichemicals.com/ID/en/p/H0193
For research and laboratory use only, not for human consumption.
