Catalytic Ligand for Room-Temperature Ullmann-Type Coupling Reaction
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N-([Biphenyl]-2-yl)-N'-(2-phenyl-1-naphthyl)-1,2-benzenediamine [B6606] serves as a catalytic ligand for copper(I) iodide (CuI) in Ullmann-type coupling reactions. Its key advantage is that the reaction can proceed at room temperature. As an example, the coupling of 3-bromoquinoline [B1013] with 1-(4-chlorobenzhydryl)piperazine [C1611] was carried out using sodium methoxide [S0485] in DMSO for 22 hours at room temperature under a nitrogen atmosphere. After purification by silica gel column chromatography, the product 3-[4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl]quinoline was obtained as a light yellow solid in 82% yield. The reaction was monitored by NMR.
Related products
- TCI B1013 5332-24-1 3-Bromoquinoline
- TCI C1611 303-26-4 1-(4-Chlorobenzhydryl)piperazine
- TCI B6606 2897656-97-0 N1-([1,1'-Biphenyl]-2-yl)-N2-(2-phenylnaphthalen-1-yl)benzene-1,2-diamine
- TCI C2163 7681-65-4 Copper(I) Iodide
Source
- TCI Practical Example: www.tcichemicals.com/ID/en/product/tci-topics/TCIPracticalExample_20250825
- TCI product page B1013: tcichemicals.com/ID/en/p/B1013
For research and laboratory use only, not for human consumption.
