TCI C1611 1-(4-Chlorobenzhydryl)piperazine (CAS 303-26-4) is a heterocyclic building block featuring the well-known benzhydrylpiperazine core with one free ring nitrogen. That differentiated nitrogen allows selective N-alkylation or N-acylation without an additional protection step, shortening synthetic routes. It is commonly used in medicinal chemistry research and in the preparation of analogue series for structure-activity studies. AMI Scientific offers this TCI intermediate in 1 g and 5 g research packs, and it should be handled in a well-ventilated area following the manufacturer's SDS.
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- Yarim et al. (2012). Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives. International Journal of Molecular Sciences doi:10.3390/ijms13078071
- Gurdal et al. (2017). Comparison of separation performance of polysaccaride-based chiral stationary phases in enantioseparation of 1-(4-chlorobenzhydryl)piperazine benzamide derivatives by HPLC. Journal of Analytical Chemistry doi:10.1134/s1061934817020046
- Kam et al. (2005). Antagonistic effects of novel non-peptide chlorobenzhydryl piperazine compounds on contractile response to bradykinin in the guinea-pig ileum. European Journal of Pharmacology doi:10.1016/j.ejphar.2005.09.010
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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