Encapsulated CuTC Enables Goldberg Amination Without Weighing the Catalyst
Share
Encapsulated CuTC [R0315] is CuTC supplied in water-soluble HPMC (hydroxypropyl methylcellulose) capsules for Goldberg amination. Each capsule contains ca. 650 μmol of CuTC, so the catalyst does not need to be weighed. The capsule disintegrates in the solvent in about 15 minutes, releasing its content into the reaction mixture. TCI demonstrated its use in the synthesis of 1-(2-nitrophenyl)-1H-imidazole from 1-bromo-2-nitrobenzene and imidazole, with potassium carbonate as base in DMSO at 140 °C for 2 hours. The reaction was monitored by GC and gave the product (43 mg, 36% yield) as a pale yellow solid after silica gel chromatography. The capsule format is intended for reaction screening and parallel synthesis.
Related products
- TCI B0622 577-19-5 1-Bromo-2-nitrobenzene
- TCI I0001 288-32-4 Imidazole
- TCI P1748 584-08-7 Potassium Carbonate
- TCI C2312 68986-76-5 Copper(I) 2-Thiophenecarboxylate
Source
- TCI Practical Example: www.tcichemicals.com/ID/en/product/tci-topics/TCIPracticalExample_20251020
- TCI product page B0622: tcichemicals.com/ID/en/p/B0622
For research and laboratory use only, not for human consumption.
