Environmentally Friendly Solvents with Diverse Applications: Deep Eutectic Solvents (DESs)

Environmentally Friendly Solvents with Diverse Applications: Deep Eutectic Solvents (DESs)

Deep Eutectic Solvents (DESs), such as Choline Chloride Urea (1:2) Eutectic Mixture (C4110), are environmentally friendly solvents. When solid choline chloride (melting point 302 °C) and urea (melting point 133 °C) are mixed in a 1:2 ratio, they form a eutectic mixture that remains liquid even at room temperature (freezing point 12 °C).¹) This phenomenon has been reported for various combinations of hydrogen bond donors and acceptors. Due to their many advantages, DESs have been studied for applications similar to those of ionic liquids.²) For example, they are used in asymmetric organocatalytic reactions with recovery and reuse of the catalyst-containing medium,³) and in Negishi-type C(sp2)–C(sp3) cross-coupling reactions carried out in a short time.⁴) DESs have also been applied in enzyme-catalyzed biodiesel fuel synthesis⁵) and as extraction solvents for natural products and biopolymers such as nucleic acids. Thus, DESs are highly valuable solvents for sustainable process development and recycling.

Related products

References

  1. Novel solvent properties of choline chloride/urea mixtures
  2. A. P. Abbott, G. Capper, D. L. Davies, R. K. Rasheed, V. Tambyrajah, Chem. Commun. 2003, 70.
  3. Metal-Free Deep Eutectic Solvents: Preparation, Physical Properties, and Significance
  4. B. Gurkan, H. Squire, E. Pentzer, J. Phys. Chem. Lett. 2019, 10, 7956.
  5. L-Isoleucine in a Choline Chloride/Ethylene Glycol Deep Eutectic Solvent: A Reusable Reaction Kit for the Asymmetric Cross-Aldol Carboligation
  6. N. Fanjul-Mosteirín, C. Concellón, V. delAmo, Org. Lett. 2016, 18, 4266.
  7. Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands
  8. G. Dilauro, C. S. Azzollini, P. Vitale, A. Salomone, F. M. Perna, V. Capriati, Angew. Chem. Int. Ed. 2021, 60, 10632.
  9. Choline-based deep eutectic solvents for enzymatic preparation of biodiesel from soybean oil
  10. H. Zhao, C. Zhang, T. D. Crittle, J. Mol. Catal. B Enzym. 2013, 85, 243.
  11. << Prev
  12. Next >>
  13. Page Top

Source

Ask AMI via WhatsApp

For research and laboratory use only, not for human consumption.

Back to blog