Buchwald Ligands and Complexes [Catalysis]

Buchwald Ligands and Complexes [Catalysis] — contains biaryl phosphines with bulky alkyl substituents such as dialkyl, di-tert-butyl, or dicyclohexyl, together with related transition metal complexes, designed as supporting ligands in palladium and nickel catalysis. Their electron-rich, bulky biaryl structure stabilizes low-coordinate metal species during the catalytic cycle.

Buchwald ligands and their complexes are widely used by synthetic chemists in cross-coupling reactions such as Suzuki-Miyaura, Buchwald-Hartwig amination, and C-N/C-O bond formation on less reactive aryl chloride or bromide substrates. The combination of basicity and steric bulk of these ligands allows catalysis at lower temperatures and with smaller palladium loadings, so they are often used in developing synthesis processes for active ingredients and functional materials at laboratory scale.

Example products in this collection: TCI R0302 564483-18-7 Xphos (HPMC encapsulated), TCI B6221 894086-00-1 5-(Di-tert-butylphosphino)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole, TCI D5664 1070663-78-3 Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine, TCI D3387 224311-51-7 2-(Di-tert-butylphosphino)biphenyl, TCI D5663 1160861-53-9 Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine, TCI D3388 247940-06-3 2-(Dicyclohexylphosphino)biphenyl, TCI D5039 564483-19-8 2-Di-tert-butylphosphino-2',4',6'-triisopropylbiphenyl, TCI D3389 213697-53-1 2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl.

Pay attention to whether the product is a free ligand or a ready-to-use precatalyst complex, as well as its physical form, such as HPMC-encapsulated powder that makes handling and weighing in open air easier. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other categories at the same level under Cross-Coupling [Catalysis], often used together in one laboratory workflow:

Back to Cross-Coupling [Catalysis]. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.

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