Buchwald Ligands [Catalysis]

Buchwald Ligands [Catalysis] — covers bulky, electron-rich biaryl phosphine families, such as dialkylbiarylphosphine derivatives with additional isopropyl or methoxy groups on the biaryl ring, which function as supporting ligands for transition metals. Their steric and electronic design enables efficient formation of active complexes with palladium or nickel.

Buchwald Ligands are chosen by synthetic chemists to assemble in situ catalysts in cross-coupling reactions such as Suzuki, Negishi, or Buchwald-Hartwig amination, especially when the substrate is an aryl chloride that is electronically less reactive. Variation of alkoxy and isopropyl substituents on the biaryl ring allows tuning of ligand basicity and steric bulk to optimize conversion on heteroaryl or ortho-substituted substrates that are sterically challenging.

Example products in this collection: TCI R0302 564483-18-7 Xphos (HPMC encapsulated), TCI B6221 894086-00-1 5-(Di-tert-butylphosphino)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole, TCI D5664 1070663-78-3 Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine, TCI D3387 224311-51-7 2-(Di-tert-butylphosphino)biphenyl, TCI D5663 1160861-53-9 Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine, TCI D3388 247940-06-3 2-(Dicyclohexylphosphino)biphenyl, TCI D5039 564483-19-8 2-Di-tert-butylphosphino-2',4',6'-triisopropylbiphenyl, TCI D3389 213697-53-1 2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl.

Choose a ligand based on the biaryl ring substitution pattern (isopropyl, methoxy, or alkoxy) that suits the planned substrate-catalyst pair, and check product stability against oxidation if stored as the free phosphine. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under Cross-Coupling [Catalysis], often used together in one laboratory workflow:

Back to Cross-Coupling [Catalysis]. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official distributor of TCI Japan in Indonesia — to check availability and lead time directly from Japan.

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