Collection: MacMillan Imidazolidinone Organocatalysts [Asymmetric Synthesis]
MacMillan Imidazolidinone Organocatalysts [Asymmetric Synthesis] — a collection of chiral imidazolidinone derivatives known as MacMillan catalysts, small organic metal-free compounds that activate carbonyl groups through the temporary formation of an iminium ion. Their main role is to induce enantiomeric selectivity in addition and cycloaddition reactions without requiring transition metal complexes.
MacMillan imidazolidinone catalysts are used by asymmetric synthesis researchers for Diels-Alder, Michael, and conjugate alkylation reactions on α,β-unsaturated aldehydes and ketones, yielding products with high enantiomeric selectivity. The hydrochloride salt form is commonly used because it is more stable and easier to handle before being neutralized into the active free base within the reaction mixture. Organic catalysis and synthesis methodology research groups often use them as an alternative to metal-based catalysts.
Product examples in this collection: TCI T2991 278173-23-2 (S)-(-)-5-Benzyl-2,2,3-trimethyl-4-imidazolidinone Hydrochloride, TCI B4137 390766-89-9 (2R,5R)-(+)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone, TCI T2990 323196-43-6 (R)-(+)-5-Benzyl-2,2,3-trimethyl-4-imidazolidinone Hydrochloride, TCI B4138 346440-54-8 (2S,5S)-(-)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone.
The choice depends on the (R) or (S) stereochemical configuration that matches the target product, as well as the hydrochloride salt form versus the free base tert-butyl form, which affect handling and solubility in reaction solvents. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.
Other parallel categories under Asymmetric Synthesis, often used together in a single laboratory workflow:
Back to Asymmetric Synthesis. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official distributor of TCI Japan in Indonesia — for availability checks and lead times directly from Japan.
