Non-Detergents Sulfobetaines (NDSB)

Non-Detergents Sulfobetaines (NDSB) — a group of zwitterionic compounds derived from sulfobetaine that are non-detergent, meaning they do not form micelles at low concentrations and therefore do not interfere with protein activity. This group is commonly used as an additive in buffer solutions to help dissolve and stabilize proteins during biochemical research.

Non-Detergents Sulfobetaines are used by biochemistry and molecular biology researchers as additives in buffers for protein isolation, refolding, and crystallization, especially for membrane proteins that are difficult to dissolve. Compounds such as sulfopropyl pyridinium derivatives are added during the extraction stage or two-dimensional electrophoresis to improve solubility without forming micelles that could obscure analysis results. This group is also used in optimizing protein crystallization conditions for structural studies.

Example products in this collection: TCI B4030 570412-84-9 4-tert-Butyl-1-(3-sulfopropyl)pyridinium Hydroxide Inner Salt [for Biochemical Research], TCI H1399 38880-58-9 (2-Hydroxyethyl)dimethyl(3-sulfopropyl)ammonium Hydroxide Inner Salt [for Biochemical Research], TCI S0813 15471-17-7 1-(3-Sulfopropyl)pyridinium Hydroxide Inner Salt [for Biochemical Research].

Pay attention to the alkyl chain structure and head group of each sulfobetaine, as they affect the solubility profile of the target protein, and choose a purity grade suitable for sensitive biochemical applications. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other categories parallel to Detergents (for Biochemistry), often used together in one laboratory workflow:

Back to Detergents (for Biochemistry). For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.

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