Collection: trans-Cyclooctenes (TCO) [Conjugation Chemistry/Click Chemistry]

trans-Cyclooctenes (TCO) [Conjugation Chemistry/Click Chemistry] — includes strained-ring trans-cyclooctene (TCO) derivatives, including TCO* variants with PEG linkers and functional groups such as NHS ester, maleimide, DBCO, biotin, or amine, which serve as fast-reacting partners in cycloaddition reactions with tetrazine.

Trans-cyclooctene is used by bioorthogonal chemistry researchers and imaging probe developers for inverse electron-demand Diels-Alder (IEDDA) reactions with tetrazine derivatives, enabling fast and selective conjugation to proteins, antibodies, or cell surfaces without metal catalysts. Variants with PEG3 linkers and NHS, maleimide, or biotin groups facilitate biomolecule labeling for pretargeting and in vitro imaging applications.

Example products in this collection: TCI T4455 TCO-NHS equatorial isomer, TCI T3948 1914971-04-2 TCO-PEG3-Maleimide, TCI T4262 TCO*-PEG3-NHS equatorial isomer, TCI T3949 1621096-79-4 TCO-PEG4-NHS (contains 6% Dichloromethane at maximum), TCI T4261 TCO*-PEG3-Maleimide equatorial isomer, TCI T4126 1380349-88-1 N-(4E)-TCO-L-lysine, TCI T4260 TCO*-PEG3-DBCO equatorial isomer, TCI T4212 TCO-NPC equatorial isomer.

Choose based on geometric isomer (equatorial or axial) because it affects the reaction rate with tetrazine, as well as the type of terminal reactive group (NHS, maleimide, DBCO, biotin, or amine) that suits the conjugation target. All products are original Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under Conjugation Chemistry/Click Chemistry, often used together in one laboratory workflow:

• Terminal Alkynes [Conjugation Chemistry/Click Chemistry]
• Azides [Conjugation Chemistry/Click Chemistry]
• Crosslinker Azides/Alkynes [Conjugation Chemistry/Click Chemistry]
• Catalysts, Ligands, Reagents [Conjugation Chemistry/Click Chemistry]
• Tetrazines [Conjugation Chemistry/Click Chemistry]
• PEG Azides/Alkynes [Conjugation Chemistry/Click Chemistry]

Return to Conjugation Chemistry/Click Chemistry. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official TCI Japan distributor in Indonesia — for availability checks and lead times directly from Japan.