*tert*-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate is a heterobifunctional PEG linker featuring a terminal hydroxyl group and a protected *tert*-butyl ester, enabling controlled stepwise conjugation. It is widely utilized in the synthesis of PEGylated biomolecules, including drug-protein conjugates, surface-modified nanoparticles, and targeted delivery systems. The trioxa spacer enhances aqueous solubility and reduces immunogenicity, making it an essential building block in chemical biology and pharmaceutical research applications.
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