2-[(4-Bromophenoxy)methyl]oxirane, also known as 4-bromophenyl glycidyl ether, pairs a strained epoxide with a brominated aromatic ring. Nucleophilic ring opening of the oxirane provides rapid access to beta-amino alcohols and related functionalised scaffolds. The aryl bromide remains available for subsequent palladium-catalysed cross-coupling, enabling orthogonal synthetic strategies. TCI supplies this building block in 5 g and 25 g sizes for research laboratory use.
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- Kan et al. (2011). Crystal structure of 2,4-bis((4-bromophenoxy)methyl)- 1,3,5-trimethylbenzene, C23H22Br2O2. Zeitschrift für Kristallographie - New Crystal Structures doi:10.1524/ncrs.2011.0180
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