TCI C0224, 5-chloro-2-nitrobenzoic acid (CAS 2516-95-2), places a nitro group ortho to the carboxylic acid, giving a reactivity profile distinct from other chloronitrobenzoic acid isomers. The acid is readily converted to amides or esters with standard coupling reagents, after which nitro reduction can trigger intramolecular cyclisation toward benzimidazoles, quinazolinones, and fused lactams. The remaining aryl chloride serves as a late-stage diversification point for substitution or metal-catalysed cross-coupling. AMI Scientific supplies 25 g and 250 g packs; refer to the official TCI product data sheet and SDS for lot specifications and safe handling.
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