2-Chloro-4-nitrobenzoic Acid TCI C0764

Chemical Identity

CAS No.: 99-60-5
PubChem: CID 7448·SID 87565836
Formula: C7H4ClNO4
Molecular weight: 201.56 g/mol
Purity: >98.0%(GC)(T)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 2-chloro-4-nitrobenzoic acid
SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)C(=O)O
InChIKey: QAYNSPOKTRVZRC-UHFFFAOYSA-N
MDL: MDL00007209

Rp 582.750,00

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Dokumen Keamanan & Mutu

↓ Unduh SDS / MSDS (PDF resmi TCI)

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2-Chloro-4-nitrobenzoic Acid from TCI is a substituted benzoic acid with a chlorine atom at position 2 and a nitro group at position 4. As a non-heterocyclic building block, it puts three different functional groups on a single aromatic ring: a carboxylic acid, a halogen and a nitro group. Each of these can be modified in turn. In the laboratory, it is widely used as an intermediate in the synthesis of pharmaceutical compounds, agrochemicals, dyes and heterocyclic molecules built from aniline or benzamide derivatives.

What makes this material useful is the way its substituents affect one another. The electron-withdrawing nitro group activates the aromatic ring. This makes the chlorine atom more reactive toward nucleophilic aromatic substitution, so amines, alkoxides or thiols can be attached at that position. The nitro group can also be reduced to an amine, which opens synthetic routes to amides, ureas or heterocyclic rings. The carboxylic acid group is ready to be converted into esters, amides or acyl chlorides. This flexibility makes the compound an efficient starting material for multistep synthesis, since chemists can carry out several transformations from one well-defined precursor.

In Indonesian laboratories, 2-Chloro-4-nitrobenzoic Acid suits organic and medicinal chemistry research groups at universities, research institutes and industrial R&D facilities. It is useful for teams that design new compound libraries, explore structure–activity relationships, or develop synthetic routes to pharmaceutical and agrochemical intermediates. Because it comes from TCI, a recognised reagent brand, researchers can use it in both academic projects and applied development work where a consistent, well-characterised starting material helps keep experimental results reproducible.

Related TCI products

Nucleophilic aromatic substitution: the nitro group activates the ring, so the chlorine at position 2 can be replaced by amines, alkoxides or thiols to build new substituted aromatics.
Pharmaceutical intermediate synthesis: three functional groups that can be modified independently let medicinal chemists build drug-like scaffolds step by step from one precursor.
Aniline and amide derivative preparation: reducing the nitro group to an amine opens routes to amides and ureas, which are core motifs in many bioactive and specialty molecules.
Heterocycle construction: the aniline and benzamide derivatives made from this acid serve as precursors for ring-forming reactions that give heterocyclic compounds for research libraries.
Ester, amide and acyl chloride chemistry: the carboxylic acid group converts easily into esters, amides or acyl chlorides, so the molecule fits coupling reactions in agrochemical and dye synthesis.

Brand	TCI (product code C0764)
CAS number	99-60-5
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes	see the available pack options on the product page
Physical form	refer to the TCI product label and Safety Data Sheet
Storage	keep tightly closed in a cool, dry, well-ventilated place, following the TCI label and SDS

Store 2-Chloro-4-nitrobenzoic Acid in its original, tightly sealed container in a cool, dry and well-ventilated area, away from direct sunlight, heat and moisture. Keep it apart from strong oxidising agents, strong bases and reducing agents. Use clean, dry glass or chemically compatible containers when transferring portions. Wear suitable gloves, safety glasses and a lab coat, and handle the material in a fume hood or a well-ventilated area to avoid inhaling dust. Avoid contact with skin and eyes. Always check the TCI Safety Data Sheet for detailed hazard, first-aid and disposal information before use.

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