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Description
TCI C0225, 4-chloro-3-nitrobenzotrifluoride (CAS 121-17-5), combines a trifluoromethyl group with a nitro group and an aryl chloride, producing a strongly activated substrate for nucleophilic aromatic substitution under comparatively mild conditions. Phenoxides, amines, and thiolates displace the chloride cleanly, opening routes to CF₃-bearing diaryl ethers, diarylamines, and thioethers of the type frequently encountered in agrochemical and pharmaceutical research. Subsequent nitro reduction delivers trifluoromethylated anilines, valued for the metabolic stability and lipophilicity that the CF₃ group imparts. AMI Scientific supplies this liquid reagent in 25 g and 500 g packs; handle it in a fume hood and follow the official TCI SDS for full safety guidance.
