trans-Cinnamaldehyde (TCI C0352, CAS 14371-10-9) is a conjugated aromatic aldehyde best known as the principal aroma compound of cinnamon. In the laboratory it functions as a versatile non-heterocyclic building block, offering both a reactive carbonyl group and a conjugated double bond in a single molecule. It is commonly used as a model substrate in iminium organocatalysis, Michael additions, and heterocycle construction. AMI Scientific supplies it in 25 mL and 500 mL packs, and handling in a fume hood with appropriate personal protective equipment is strongly recommended.
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- Gholivand et al. (2008). Simultaneous Determination of Trans-Cinnamaldehyde and Benzaldehyde in Different Real Samples by Differential Pulse Polarography and Study of Heat Stability of Trans-Cinnamaldehyde. Analytical Letters doi:10.1080/00032710802507893
- Ali et al. (2021). Trans-Cinnamaldehyde Attenuates Enterococcus faecalis Virulence and Inhibits Biofilm Formation. Antibiotics doi:10.3390/antibiotics10060702
- Swales et al. (1996). Studies on trans-cinnamaldehyde II: Mechanisms of cytotoxicity in rat isolated hepatocytes. Toxicology in Vitro doi:10.1016/0887-2333(95)00105-0
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