TCI C0499 2-Chloro-5-nitrobenzoyl Chloride (CAS 25784-91-2) is a highly reactive aromatic acyl chloride bearing both chloro and nitro electron-withdrawing substituents. The strongly electrophilic carbonyl centre reacts rapidly with amines and alcohols, making it an efficient acylating reagent for amide and ester formation. The activated aryl chloride and the nitro group also open further routes such as nucleophilic aromatic substitution and reduction to the corresponding aniline derivative. Because the compound is corrosive and moisture-sensitive, releasing hydrogen chloride on contact with water, always handle it in a fume hood with dry glassware, anhydrous solvents, and full protective equipment.
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