TCI C0563 4-Chlorobenzamide (CAS 619-56-7) is the para isomer of chlorobenzamide, supplied as a non-heterocyclic building block for laboratory synthesis. Its amide group provides straightforward access to 4-chlorobenzoic acid by hydrolysis, to 4-chlorobenzonitrile by dehydration, and to the corresponding benzylamine by reduction. The strong, directional hydrogen bonding of the amide functionality also makes it a useful model compound in crystal engineering and cocrystal research. Keep the solid in a tightly closed container in a cool, dry, light-protected place, and handle it with gloves and eye protection while avoiding dust formation.
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- (2024). Docking studies, molecular structure, and spectroscopic analysis of 3-chlorobenzamide as an anti-cancer agent. Indian Journal of Biochemistry and Biophysics doi:10.56042/ijbb.v61i4.8236
- Qingxiang et al. (2000). Study on the Hydrolysis of 2-Chlorobenzamide. Journal of Agricultural and Food Chemistry doi:10.1021/jf990163a
- Zhao et al. (2013). Crystal structure of 14-O-[(4-chlorobenzamide-2-methylpropane-2-yl)-thioacetate] mutilin diethanol solvate, C37H58ClNO7S. Zeitschrift für Kristallographie - New Crystal Structures doi:10.1524/ncrs.2013.0154
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