N-Carbobenzoxy-beta-alanine TCI C0640

Chemical Identity

Other names: Z-β-Ala-OH · N-Cbz-beta-alanine · Z-beta-Ala-OH · N-Benzyloxycarbonyl-beta-alanine
CAS No.: 2304-94-1
PubChem: CID 75313·SID 87565730
Formula: C11H13NO4
Molecular weight: 223.23 g/mol
Purity: >98.0%(T)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 3-(phenylmethoxycarbonylamino)propanoic acid
SMILES: C1=CC=C(C=C1)COC(=O)NCCC(=O)O
InChIKey: GEVGRLPYQJTKKS-UHFFFAOYSA-N
MDL: MDL00037292

Rp 557.550,00

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Dokumen Keamanan & Mutu

↓ Unduh SDS / MSDS (PDF resmi TCI)

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N-Carbobenzoxy-beta-alanine from TCI, also known as Z-β-Ala-OH or Cbz-β-alanine, is a derivative of the amino acid β-alanine. Its amino group is protected by a benzyloxycarbonyl group (Cbz or Z). The compound belongs to the peptide chemistry category and serves as a protected building block in the synthesis of peptides, peptidomimetics, and bioactive molecules. Because the amine group is already protected, the carboxyl group can be activated and coupled selectively without the risk of self-polymerization, which is an essential requirement in stepwise peptide synthesis.

Chemists often choose the Cbz protecting group because it is stable under many reaction conditions, including mildly basic and weakly acidic conditions. It can be removed cleanly by catalytic hydrogenolysis or with certain strong acids, which lets researchers plan when to deprotect within a longer synthetic route. As a β-amino acid, β-alanine has one extra carbon atom between its amine and carboxyl groups. This gives the chain more flexibility and makes it more resistant to protease enzymes than α-amino acids. Together, these features make Z-β-Ala-OH useful as a linker, a spacer, or a building unit for β-peptides.

In Indonesian laboratories, this material is relevant to research groups working in peptide chemistry, including university organic and medicinal chemistry laboratories, pharmaceutical research and development teams, and chemical biology groups. These users need reliable protected amino acid building blocks for multi-step synthesis. Researchers who design modified peptides, flexible linkers, or protease-resistant structures can use Z-β-Ala-OH as a dependable starting material in their synthetic routes, and AMI Scientific supplies it under the TCI brand.

TCI brochures (PDF)

Amino Acids and Peptide Synthesis Reagents 2025-08-14 · p. 17

Related TCI products

Stepwise peptide synthesis: the protected amine stops self-polymerization, so the carboxyl group can be activated and coupled selectively to build peptide chains in a controlled sequence.
Peptidomimetic design: the β-amino acid backbone makes the chain more resistant to protease enzymes than α-amino acids, which helps researchers build peptide-like molecules with improved stability.
Linker and spacer construction: the extra carbon between the amine and carboxyl groups adds chain flexibility, so the compound works well for joining functional units or adding space between molecular segments.
β-peptide synthesis: as a protected β-alanine unit, Z-β-Ala-OH can be built directly into β-peptide sequences that researchers study for their distinct structures and stability.
Bioactive molecule synthesis: the Cbz group withstands mildly basic and weakly acidic conditions and can later be removed by catalytic hydrogenolysis or certain strong acids, which suits multi-step routes to bioactive targets.

Brand	TCI (product code C0640)
CAS number	2304-94-1
Molecular formula	—
Purity	—
Category	Chemistry > Chemical Biology > Peptide Chemistry
Pack sizes	as listed on the TCI product page; please confirm with AMI Scientific
Physical form	—
Storage	follow the conditions stated on the TCI label and Safety Data Sheet (SDS)

Synonyms: Z-β-Ala-OH, Cbz-β-alanine

Store N-Carbobenzoxy-beta-alanine in its original, tightly closed container in a cool, dry, well-ventilated place, away from moisture, heat sources, and direct sunlight. Follow any specific storage temperature on the TCI label or Safety Data Sheet. Keep the container closed when not in use to prevent contamination and moisture uptake. Handle the material in a well-ventilated area or a fume hood, and wear standard personal protective equipment, including a lab coat, safety glasses, and chemical-resistant gloves. Avoid creating or inhaling dust, and avoid contact with skin and eyes. Use clean, dry spatulas and glassware when weighing to protect the material's quality. Label all containers clearly, read the SDS before first use, and dispose of residues and waste according to institutional and local chemical waste regulations.

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