TCI C0783 1-Cyanoadamantane (CAS 23074-42-2) is a nitrile building block featuring the rigid, lipophilic adamantane cage. Its cyano group serves as a convenient handle for conversion into carboxylic acids, amides, primary amines, and selected heterocyclic systems. Researchers frequently employ it in medicinal chemistry programmes where an adamantyl motif is used to tune molecular properties. Supplied by TCI in 1 g and 5 g packs, it suits exploratory and optimisation-scale synthetic work.
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- CATHIAUX (1999). A molecular dynamics study of model cyanoadamantane. Molecular Physics doi:10.1080/002689799164865
- KACZOR (2004). Dipolar absorption in liquid cyanoadamantane cluster?computer simulations. Journal of Molecular Structure doi:10.1016/s0022-2860(04)00284-4
- Fabianski et al. (2003). Polymorphism of cyanoadamantane crystal. Phase Transitions doi:10.1080/01411590310001613699
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