TCI C0888 Cyclobutanecarboxylic Acid (CAS 3721-95-7) is a strained four-membered cyclic carboxylic acid widely used as a non-heterocyclic building block in organic synthesis. Its carboxyl group is readily converted into amides, esters, and other acyl derivatives, making it a practical entry point for multi-step synthetic routes. The cyclobutyl motif is frequently explored in medicinal chemistry to introduce conformational rigidity and modulate the three-dimensional profile of target molecules. Available through AMI Scientific in 10 g and 25 g packs, it should be stored in a tightly closed container in a cool, dry, well-ventilated area in line with the official TCI documentation.
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- DEHMLOW et al. (1990). ChemInform Abstract: Synthesis of Stereoisomeric 3‐Substituted Cyclobutanecarboxylic Acid Derivatives.. ChemInform doi:10.1002/chin.199036116
- Grigor’ev et al. (2018). Complexes of An(VI) with Cyclobutanecarboxylic Acid Anions and Outer-Sphere Alkali Metal Cations. Radiochemistry doi:10.1134/s1066362218050065
- Kabalka et al. (2005). Synthesis of a boronated amino acid as a potential neutron therapy agent: 1-amino-3-[(dihydroxyboryl)ethyl]cyclobutanecarboxylic acid. Tetrahedron Letters doi:10.1016/j.tetlet.2005.04.130
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