TCI
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Description
TCI C1104 Comanic Acid (CAS 499-05-8) is a heterocyclic building block featuring a pyranone ring bearing a carboxylic acid group. The conjugated oxygen-containing ring offers reactivity patterns distinct from ordinary aromatics, including conversion to pyridinone systems on treatment with amines. The carboxyl group provides an additional handle for amidation, esterification and metal coordination studies. AMI Scientific offers this TCI product in 1 g, 5 g and 25 g packs to suit both exploratory and routine synthetic work.
Scientific References
- Usachev et al. (2011). ChemInform Abstract: Synthesis of Regioisomeric 3‐(N‐Phenylpyrazolyl)indoles from Comanic Acid (I) and Phenylhydrazine.. ChemInform doi:10.1002/chin.201111137
- Usachev et al. (2009). Regioselective solvent-sensitive reactions of 6-(trifluoromethyl)comanic acid and its derivatives with phenylhydrazine. Tetrahedron Letters doi:10.1016/j.tetlet.2009.05.056
- Usachev et al. (2012). Regioselective synthesis of trifluoromethylated 3-(pyrazolyl)indoles on the basis of 6-(trifluoromethyl)comanic acid. Journal of Fluorine Chemistry doi:10.1016/j.jfluchem.2011.12.008
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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